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Figure 4
Structural comparison of Ca2+- and Zn2+-bound EF-hands among EFhd1, EFhd2 and other proteins. Detailed view of superimposed (a) EF-hand 1 (EF1) and (b) EF-hand 2 (EF2) in EFhd1Ca and EFhd1Zn. EFhd1Ca and EFhd1Zn are shown in lime green and teal, respectively. Detailed view of superimposed (c) EF1 and (d) EF2 in EFhd2Ca and EFhd2Zn. EFhd2Ca (PDB entry 5i2l) and EFhd2Zn are orange and magenta, respectively. Detailed view of the superimposed EF-hand-like motifs in (e) Tse3Ca in yellow (PDB entry 4n80) and Tse3Zn in purple (PDB entry 4n7s) and EF4 in (f) CaMCa in pale green (PDB entry 1cll) and CaMZn in blue (PDB entry 4hex). Detailed view of superimposed (g) EF2 and (h) EF-hand 3 (EF3) in CaMCa in pale green (PDB entry 1cll) and CaMZn in blue (PDB entry 4hex). Detailed view of superimposed (i) EF1 and (j) EF3 of ALG-2Ca in silver (PDB entry 2zn9) and ALG-2Zn in bronze (PDB entry 2zn8). In all panels, the residues for Zn2+ coordination are represented in stick form, and Zn2+ coordination is represented by dashed lines.

IUCrJ
Volume 10| Part 2| March 2023| Pages 233-245
ISSN: 2052-2525
https://doi.org/10.1107/S2052252523001501