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Figure 1
Monomer structure and sequence of the TLR15TIR domain. (a) Overall structure of a TLR15TIR monomer. The TLR15TIR monomer structure is shown as rainbow ribbons (N-terminus, blue; C-terminus, red). The triangular shape of the TLR15TIR structure is outlined by a dashed triangle, and the side of the TLR15TIR triangle that participates in dimerization is colored green. The Cys737 and Cys756 residues that form an intramolecular di­sulfide bond are represented by ball-and-stick models. (b) The TLR15TIR sequence. The secondary structures of TLR15TIR are represented by arrows and waves (β-strands and α-helices, respectively) above the TLR15TIR sequence. The dimerization interface residues of TLR15TIR are colored red. The Cys737 and Cys756 residues that participate in an intramolecular di­sulfide bond are colored blue and linked by a blue line. The Ile753, Tyr779 and Phe813 residues of TLR15 that were mutated to confirm the TLR15TIR dimerization interface are indicated by green dots below the TLR15TIR sequence.

IUCrJ
Volume 10| Part 3| May 2023| Pages 352-362
ISSN: 2052-2525
https://doi.org/10.1107/S2052252523002956