view article
Figure 5
Structural comparison of TLR15TIR with TLR10TIR and TLR6TIR. (a) Overlaid monomer structures of TLR15TIR (dimerization interface, green; other regions, light blue) and TLR10TIR (salmon; PDB ID 2j67; Nyman et al., 2008BB22). The lengths of the αB2 and αC2 helices are indicated by double-headed arrows (TLR15TIR, green; TLR10TIR, salmon). Structural differences at the BB loop are indicated by a thick single-headed arrow. (b) Overlaid monomer structures of TLR15TIR (dimerization interface, green; other regions, light blue) and TLR6TIR (salmon; PDB ID 4om7; Jang & Park, 2014BB14). The lengths of the αB2 and αC2 helices are indicated by double-headed arrows (TLR15TIR, green; TLR6TIR, salmon). The structural differences at the BB loop are indicated by a thick single-headed arrow. (c) TLR15TIR and TLR6TIR (PDB ID 4om7) structures at the αC2 helix and its neighboring regions. The TLR15 residues that are identical to the TLR6 residues are shown as magenta sticks, and those that differ are depicted as cyan sticks. TLR6 residues are represented by orange sticks. (d) Residue type-based and structure-based alignments of TLR15, TLR10 and TLR6 sequences at the αC2 helix and its neighboring regions. The TLR10 and TLR6 residues that are identical to those of TLR15 are colored magenta.

IUCrJ
Volume 10| Part 3| May 2023| Pages 352-362
ISSN: 2052-2525
https://doi.org/10.1107/S2052252523002956