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Figure 5
Peptide groove comformational changes and three major interaction sites. (a) TAPBPR/H2-Dd (PDB entry 5wer, blue and firebrick) is superimposed with H2-Dd-5-mer (PDB entry 5wes, gray). Three major interaction sites are numbered. (b) Tapasin/HLA-B44 (PDB entry 7tue, marine blue and magenta) is superimposed with HLA-B44-6-mer (PDB entry 7tud, gray). Tapasin draws the α2–1 helix of HLA-B44 closer by about 3.0 Å and results in the groove being open. The three major interaction sites are numbered, and shown in detail in (c).

IUCrJ
Volume 11| Part 3| May 2024| Pages 287-298
ISSN: 2052-2525
https://doi.org/10.1107/S2052252524002768