Chaperone-mediated MHC-I peptide exchange in antigen presentation

Jiang, J.; Natarajan, K.; Margulies, D.H.

doi:10.1107/S2052252524002768

Figure 9
Structural mechanism of peptide exchange and illustration. (a) Structural mechanism of peptide exchange indicating dynamic intermediate states. State 1 indicates β₂m binding to the heavy chain of MHC-I. State 2 shows the early loading of low-affinity peptides. State 3 displays the initial interaction of tapasin binding to MHC-I. State 4 summarizes the release of the lower-affinity peptide and formation of a peptide receptive complex. State 5 illustrates the binding of a high-affinity peptide, releasing MHC-I from the PLC. (b) The Finger–Palm–Heel model: a mechanical principle [This figure is modified from one previously published by Jiang et al. (2022