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Figure 3
Affinity measurements of benzenesulfonamide-bearing compound VD10-13 binding to CA IX by using four different techniques: (a) FTSA, (b) SFA of CO2 hydration enzymatic activity inhibition, (c) ITC and (d) competition assay for cell-expressed CA IX. The insets show raw data curves, while the main panels show processed data dosing curves used for dissociation constant (Kd) calculation.

IUCrJ
Volume 11| Part 4| July 2024| Pages 556-569
ISSN: 2052-2525
https://doi.org/10.1107/S2052252524004627