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Figure 5
Temperature-dependent difference in compound binding mode. The RT structure from crystals soaked with compound 7 is compared with the RT apo structure and the cryo-T structure in complex with compound 7. (a) In the RT structure of sEH obtained from crystals soaked with compound 7, the active-site density is best fitted with a PEG fragment (PDB entry 8qwg). (b) RT apo structure with a PEG fragment bound in the active site (PDB entry 8qvm). (c) In the cryo-T structure from crystals soaked with compound 7 (PDB entry 5ai8; Öster et al., 2015 ![]() |
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ISSN: 2052-2525
BIOLOGY | MEDICINE
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