Figure 8
Ordering of loops. An example of a loop (Pro65 to Ala95) with a higher degree of order in the RT structures compared with in the cryo-T structures. (a) 2FoFc electron density map associated with crystals soaked with compound 7 at RT (PDB entry 8qwg). (b) 2FoFc electron density map associated with the corresponding cryo-T structure (PDB entry 5ai8). The 2FoFc electron density maps are contoured at 1σ (blue). |