Binding structures of SERF1a with NT17-polyQ peptides of huntingtin exon 1 revealed by SEC-SWAXS, NMR and molecular simulation

Lin, T.-C.; Shih, O.; Tsai, T.-Y.; Yeh, Y.-Q.; Liao, K.-F.; Mansel, B.W.; Shiu, Y.-J.; Chang, C.-F.; Su, A.-C.; Chen, Y.-R.; Jeng, U.-S.

doi:10.1107/S2052252524006341

Figure 1
(a) Elution profiles of R_g, zero-angle intensity I₀ and non-aggregation number values near N = 1, deduced from the integrated analysis of SAXS I₀ and optical data of SERF1a. (b) SWAXS data of SERF1a are fitted using an NMR model (inset) and the SWAXS-NMR model (inset, scaled with a bar for 10 Å size). The data and model are deposited in the SASBDB database with the code SASDVL5 (Kikhney et al., 2020

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