Binding structures of SERF1a with NT17-polyQ peptides of huntingtin exon 1 revealed by SEC-SWAXS, NMR and molecular simulation

Lin, T.-C.; Shih, O.; Tsai, T.-Y.; Yeh, Y.-Q.; Liao, K.-F.; Mansel, B.W.; Shiu, Y.-J.; Chang, C.-F.; Su, A.-C.; Chen, Y.-R.; Jeng, U.-S.

doi:10.1107/S2052252524006341

Figure 3
(a) SWAXS data of Htt-0 (SASDVP5) are fitted using the Rosetta model shown in the inset (the scale bar in the inset is for 10 Å). (b) SWAXS data of Htt-1SASDVQ5 are fitted using the dimer models optimized by Rosetta-fastsaxs and SASREF, as shown in the insets. Also shown is the profile calculated with a helical monomer model of Htt-1.

IUCrJ

Volume 11| Part 5| September 2024| Pages 849-858

ISSN: 2052-2525

https://doi.org/10.1107/S2052252524006341

BIOLOGY | MEDICINE

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