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Figure 5
(a) Evolutions of Rg, decomposed concentrations of SERF1a and Htt-3 in µM, and the molar ratio M of the complex of Htt-3/SERF1a, over the SEC-SAXS elution peak. (b) The SEC-SAXS data, merged from the data frames shadowed in (a), are fitted (solid curve with χ2 = 2.19) using a representative Rosetta model (inset; SASDVS5) comprising one SERF1a and one Htt-3. Furthermore, (c) and (d) are zoom-in views of the two binding sites of Htt-3 (via Thr3 and Pro28 of the NT17-polyQ) with the N-terminal side (Asn5 and Lys23 amino acids) of SERF1a.

IUCrJ
Volume 11| Part 5| September 2024| Pages 849-858
ISSN: 2052-2525
https://doi.org/10.1107/S2052252524006341