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Figure 1
Representative TIR domain crystal structures. (a)–(d) Structures of TIR domains (coloured depending on their B factors) from (a) TLR1, (b) L6, (c) BcThsB and (d) MAL are represented as ribbons. (e)–(h) Crystal contact based TIR-domain assemblies observed in the structures of (e) TRR2 (magenta), (f) RPS4 (yellow), (g) L6 (pink) and (h) TcpB (teal). The BE interface involves residues from the BB loop of one TIR domain subunit and residues from the βD strand, βE strand and αE helix of the next subunit. The BCD interface involves residues from the αC helix and either the αB/BB-loops or the αD region, or both. The AE interface involves residues in the EE loop, αA helix and αE helix of both subunits, whereas the DE interface predominantly involves residues from the αD and αE helices. The DD/EE loop interface involves the DD and EE loops.

IUCrJ
Volume 11| Part 5| September 2024| Pages 695-707
ISSN: 2052-2525
https://doi.org/10.1107/S2052252524007693