view article
Figure 6
Structures of TIR domain enzyme assemblies stabilized by chemical `glues'. (a) Crystal structures of SARM1 TIR domain in complex with 1AD (teal), 2AD (orange) and 3AD (magenta), respectively. (b) Cryo-EM structures of the TIR domain assembly of AbTir (light-purple cartoon) and SARM1 (teal cartoon) stabilized by 3AD (red stick) and 1AD (yellow stick), respectively. (c) Stick representation of the active sites in SARM1 and AbTir. Residues with * are from the adjacent TIR domains.

IUCrJ
Volume 11| Part 5| September 2024| Pages 695-707
ISSN: 2052-2525
https://doi.org/10.1107/S2052252524007693