A new statistical metric for robust target detection in cryo-EM using 2D template matching

Zhang, K.; Cossio, P.; Rangan, A.V.; Lucas, B.A.; Grigorieff, N.

doi:10.1107/S2052252524011771

Figure 11
High 2DTM SNR values identify locations that overlap with protein particles. Shown are locations in two example mixed-particle montages where the 2DTM SNR is greater than 8.0: (a) a clathrin and proteasome mixture and (b) a clathrin and mature 60S mixture. This demonstrates that the 2DTM SNR can function as a blob detector.

IUCrJ

Volume 12| Part 2| March 2025|

ISSN: 2052-2525

https://doi.org/10.1107/S2052252524011771

CRYO | EM

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