A new statistical metric for robust target detection in cryo-EM using 2D template matching

Zhang, K.; Cossio, P.; Rangan, A.V.; Lucas, B.A.; Grigorieff, N.

doi:10.1107/S2052252524011771

Figure 7
Structure of the clathrin monomer used as the template for 2DTM searches. Shown are different views of the complete clathrin invariant hub (blue), determined from single-particle cryo-EM, and the clathrin monomer (orange) used as the template in our experiments. The monomer consists of three heavy chains and two light chains, with a molecular weight of 193 kDa.

IUCrJ

Volume 12| Part 2| March 2025|

ISSN: 2052-2525

https://doi.org/10.1107/S2052252524011771

CRYO | EM

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