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Figure 4
Mapping homolog-specific regional conformational variability in HSP90 bound to RDC. Difference in χ1 Ringer peaks between human and C. albicans Hsp90α–RDC mapped onto the front (a) and back (b) of human Hsp90α–RDC. The red surface coloring corresponds to more alternative conformers as peaks in electron-density maps in the C. albicans protein and the blue surface corresponds to more peaks in human Hsp90α bound to RDC (shown as yellow sticks). Ringer plots are shown for binding-site residues with alternative conformations between homologs. This is also supported by mapping Pearson CC values for χ1 (c) and χ2 (d) onto the protein surface.

IUCrJ
Volume 12| Part 2| March 2025| Pages 245-254
ISSN: 2052-2525
https://doi.org/10.1107/S2052252525001332