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Figure 4
Two categories arise from the binding of fragments at the ATP-binding site. (a) An apo-like conformation is observed upon the binding of 19 fragments. None of the fragments interacted with ATP, and the Leu107–Val111 region forms a loop-like structure. (b) A distinct conformation, differing from that of ATP binding, is noted. In this case, 44 fragments stacked together like hairpins, and the Leu107–Gly114 segment formed a complete α-helix.

IUCrJ
Volume 12| Part 2| March 2025|
ISSN: 2052-2525
https://doi.org/10.1107/S2052252524012247