Understanding the selectivity of nonsteroidal anti-inflammatory drugs for cyclooxygenases using quantum crystallography and electrostatic interaction energy

Pawlędzio, S.; Ziemniak, M.; Wang, X.; Woźniak, K.; Malinska, M.

doi:10.1107/S2052252525000053

Figure 3
Schematic representation of the active site of COX-1 and COX-2. CBD, PBP and DBP denote the central binding pocket, proximal binding pocket and distal binding pocket, respectively. This figure was reproduced from The Lancet (Hawkey, 1999

) with permission from Elsevier.