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Figure 8
Arrangement of the N—H donors forming the oxyanion hole relative to the substrate amide (or product carb­oxy­lic in 3eca) group. The substrate/product amide/carb­oxy­lic plane is horizontal and roughly perpendicular to the plane of projection, with the C=Oδ1 bond pointing away from the viewer. The cases of (a) class 1 enzyme (PDB ID 3eca) and (b) class 3 enzyme (PDB ID 9g66).

IUCrJ
Volume 13| Part 2| March 2026| Pages 132-145
ISSN: 2052-2525
https://doi.org/10.1107/S2052252525010826