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Figure 1
(A) Schematic drawing of the two 25-base-pair DNA duplexes studied: a pure AT duplex (`AT DNA', left) in which one strand contains only thymine bases and its complement only adenine, forming an A-tract-like B* variant, and a B-form mixed-sequence duplex (`Mix DNA', right) comprised of two 8–10-base-pair GC-rich segments at both ends flanking a 7-base-pair AT-rich core. (B) WAXS intensity profiles of AT DNA (blue) and Mix DNA (orange). The curves were offset for visual separation. The inset highlights the low-q (SAXS) region, where the shapes of the two curves are similar and yield similar Rg (21.9 ± 0.1 Å for AT DNA and 22.9 ± 0.1 Å for Mix DNA). At higher angles (q > 0.3 Å−1), WAXS profiles for AT DNA exhibit sharp periodic peaks between q values of 0.6–2.0 Å−1, whereas Mix DNA exhibits broader features in WAXS.

IUCrJ
Volume 13| Part 5| September 2026| Pages 650-658
ISSN: 2052-2525
https://doi.org/10.1107/S2052252526007700