A strategy for collecting isomorphous derivative data with the oscillation method

A strategy is described for the collection of isomorphous derivative data using the oscillation method. An example of this procedure is given using the uranyl derivative of southern bean mosaic virus. The method is based on rapid collection and processing of an initial low-resolution (large oscillation angle) data set which is used to characterize the derivative before proceeding to high-resolution (small oscillation angle) photography.