4,12,16,24-Tetrahydroxycalix[4]arene–Methanol (1/2)

The calixarene moiety in the title compound, 4,12,16,24-tetrahydroxypentacyclo­[19.3.1.1^3,7.1^9,131^15,19]octacosa- 1(25),3,5,7(28),9,11,13 (27),15,17,19 (26),21,23-dodecaene methanol solvate(1:2), C₂₈H₂₄O₄.2CH₄O assumes a 1,2-alternate conformation in the crystalline state which allows two intramolecular O—H...O hydrogen bonds to be formed between pairs of adjacent phenolic OH groups. The mol­ecules are arranged in the crystal to form infinite chains connected via intermolecular hydrogen bonds involving the two bridging methanol molecules. 12-Membered cyclic arrays of six hydrogen-bonded OH groups are formed with O...O 2.618 (3)–2.742 (2) Å.

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