Supporting information
Crystallographic Information File (CIF) https://doi.org/10.1107/S1600536807034836/at2335sup1.cif | |
Structure factor file (CIF format) https://doi.org/10.1107/S1600536807034836/at2335Isup2.hkl |
CCDC reference: 653953
2-(Amino-benzylsulfanyl-methylene)-malononitrile (1.29 g, 10 mmol) and acetylacetone (0.72 g, 12 mmol) were added to a solution of zinc nitrate (3.56 g, 20 mmol) in ethanol (15 ml) at room temperature while stirring. The mixture was then refluxed for 12 h. The precipitate was filtered and washed with water, recrystallized from ethanol to give the title compound (yield 59%). Red crystals of (I) suitable for X-ray structure analysis were grown from ethanol.
All H atoms were placed in calculated positions, with N—H = 0.86 Å and C—H distances in the range 0.93–0.97 Å, and included in the final cycles of refinement using a riding-model approximation, with Uiso(H) = 1.2–1.5Ueq(carrier atom).
Pyridine derivatives are important compounds in terms of pesticides and medicines (Bretschneider et al., 1999; Hirano 2000; Hui et al., 2000; Nicholas et al., 2000). We report here the molecular structure of the title compound (I).
In the title compound (I), all bond lengths and angles are within normal ranges (Allen et al., 1987) and the crystal structure are stabilized by intra and intermolecular hydrogen bonds (Table 1).
For biological and pharmaceutical activity of pyridines, see Psnreddy et al. (1987); Hui et al. (2000). Many derivatives of pyridines have been prepared by Bretschneider et al. (1999) and Hirano (2000). For related literature, see: Allen et al. (1987); Lin et al. (2002); Nicholas & Molinskiet (2000).
Data collection: SMART (Bruker, 2000); cell refinement: SAINT (Bruker, 2000); data reduction: SAINT; program(s) used to solve structure: SHELXS97 (Sheldrick, 1997); program(s) used to refine structure: SHELXL97 (Sheldrick, 1997); molecular graphics: SHELXTL (Bruker, 1997); software used to prepare material for publication: SHELXTL.
Fig. 1. The structure of (I). showing 50% probability displacement ellipsoids and the atom-numbering scheme. | |
Fig. 2. Crystal packing diagram of (I). Hydrogen bonds are shown as dashed lines. |
C16H15N3OS | Z = 2 |
Mr = 297.37 | F(000) = 312 |
Triclinic, P1 | Dx = 1.303 Mg m−3 |
Hall symbol: -P 1 | Mo Kα radiation, λ = 0.71073 Å |
a = 8.6850 (5) Å | Cell parameters from 822 reflections |
b = 9.9127 (6) Å | θ = 2.5–19.2° |
c = 10.3236 (7) Å | µ = 0.22 mm−1 |
α = 111.007 (1)° | T = 295 K |
β = 105.027 (1)° | Block, red |
γ = 101.552 (1)° | 0.16 × 0.10 × 0.10 mm |
V = 757.78 (8) Å3 |
Bruker SMART CCD area-detector diffractometer | 2621 independent reflections |
Radiation source: fine-focus sealed tube | 1413 reflections with I > 2σ(I) |
Graphite monochromator | Rint = 0.025 |
φ and ω scans | θmax = 25.0°, θmin = 2.3° |
Absorption correction: multi-scan (SADABS; Bruker, 2000) | h = −10→8 |
Tmin = 0.966, Tmax = 0.979 | k = −11→11 |
5133 measured reflections | l = −12→12 |
Refinement on F2 | Primary atom site location: structure-invariant direct methods |
Least-squares matrix: full | Secondary atom site location: difference Fourier map |
R[F2 > 2σ(F2)] = 0.063 | Hydrogen site location: inferred from neighbouring sites |
wR(F2) = 0.179 | H-atom parameters constrained |
S = 0.99 | w = 1/[σ2(Fo2) + (0.0923P)2] where P = (Fo2 + 2Fc2)/3 |
2621 reflections | (Δ/σ)max < 0.001 |
192 parameters | Δρmax = 0.17 e Å−3 |
0 restraints | Δρmin = −0.16 e Å−3 |
C16H15N3OS | γ = 101.552 (1)° |
Mr = 297.37 | V = 757.78 (8) Å3 |
Triclinic, P1 | Z = 2 |
a = 8.6850 (5) Å | Mo Kα radiation |
b = 9.9127 (6) Å | µ = 0.22 mm−1 |
c = 10.3236 (7) Å | T = 295 K |
α = 111.007 (1)° | 0.16 × 0.10 × 0.10 mm |
β = 105.027 (1)° |
Bruker SMART CCD area-detector diffractometer | 2621 independent reflections |
Absorption correction: multi-scan (SADABS; Bruker, 2000) | 1413 reflections with I > 2σ(I) |
Tmin = 0.966, Tmax = 0.979 | Rint = 0.025 |
5133 measured reflections |
R[F2 > 2σ(F2)] = 0.063 | 0 restraints |
wR(F2) = 0.179 | H-atom parameters constrained |
S = 0.99 | Δρmax = 0.17 e Å−3 |
2621 reflections | Δρmin = −0.16 e Å−3 |
192 parameters |
Geometry. All e.s.d.'s (except the e.s.d. in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell e.s.d.'s are taken into account individually in the estimation of e.s.d.'s in distances, angles and torsion angles; correlations between e.s.d.'s in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell e.s.d.'s is used for estimating e.s.d.'s involving l.s. planes. |
Refinement. Refinement of F2 against ALL reflections. The weighted R-factor wR and goodness of fit S are based on F2, conventional R-factors R are based on F, with F set to zero for negative F2. The threshold expression of F2 > σ(F2) is used only for calculating R-factors(gt) etc. and is not relevant to the choice of reflections for refinement. R-factors based on F2 are statistically about twice as large as those based on F, and R- factors based on ALL data will be even larger. |
x | y | z | Uiso*/Ueq | ||
S1 | 0.26894 (14) | 0.45770 (11) | 0.72133 (11) | 0.0998 (5) | |
N1 | 0.2088 (4) | 0.4459 (3) | 0.9578 (3) | 0.0936 (9) | |
C7 | 0.3932 (4) | 0.6858 (4) | 1.0011 (4) | 0.0775 (10) | |
C3 | 0.3315 (4) | 0.6554 (4) | 1.2065 (4) | 0.0775 (10) | |
C2 | 0.3636 (5) | 0.7181 (5) | 1.3694 (4) | 0.0868 (11) | |
O1 | 0.3731 (4) | 0.8483 (3) | 1.4385 (3) | 0.1101 (9) | |
N2 | 0.4994 (4) | 0.8984 (4) | 1.2380 (4) | 0.1074 (10) | |
H2A | 0.5474 | 0.9533 | 1.2021 | 0.129* | |
H2B | 0.5093 | 0.9384 | 1.3299 | 0.129* | |
C4 | 0.2318 (5) | 0.5065 (4) | 1.1043 (5) | 0.0885 (12) | |
C6 | 0.4095 (4) | 0.7511 (4) | 1.1507 (4) | 0.0794 (10) | |
C8 | 0.2931 (5) | 0.5339 (4) | 0.9098 (4) | 0.0840 (10) | |
C9 | 0.4776 (4) | 0.7725 (4) | 0.9408 (4) | 0.0859 (10) | |
C11 | 0.0735 (5) | 0.1891 (4) | 0.4854 (5) | 0.0885 (11) | |
N3 | 0.5430 (4) | 0.8423 (4) | 0.8923 (3) | 0.1136 (11) | |
C5 | 0.1246 (5) | 0.3945 (4) | 1.1406 (5) | 0.1151 (14) | |
H5A | 0.0286 | 0.3247 | 1.0529 | 0.173* | |
H5B | 0.0870 | 0.4495 | 1.2170 | 0.173* | |
H5C | 0.1903 | 0.3385 | 1.1748 | 0.173* | |
C16 | 0.1482 (5) | 0.0911 (4) | 0.4183 (5) | 0.0974 (11) | |
H16 | 0.2369 | 0.0740 | 0.4760 | 0.117* | |
C14 | −0.0360 (7) | 0.0392 (6) | 0.1803 (6) | 0.1275 (17) | |
H14 | −0.0748 | −0.0139 | 0.0772 | 0.153* | |
C10 | 0.1286 (6) | 0.2644 (4) | 0.6516 (5) | 0.1131 (13) | |
H10A | 0.1865 | 0.2071 | 0.6935 | 0.136* | |
H10B | 0.0311 | 0.2668 | 0.6805 | 0.136* | |
C13 | −0.1093 (6) | 0.1380 (8) | 0.2438 (8) | 0.150 (2) | |
H13 | −0.1965 | 0.1558 | 0.1851 | 0.180* | |
C15 | 0.0931 (6) | 0.0166 (5) | 0.2647 (6) | 0.1173 (14) | |
H15 | 0.1457 | −0.0494 | 0.2197 | 0.141* | |
C1 | 0.3932 (6) | 0.6203 (5) | 1.4510 (4) | 0.1248 (16) | |
H1A | 0.4878 | 0.6791 | 1.5428 | 0.187* | |
H1B | 0.4159 | 0.5332 | 1.3902 | 0.187* | |
H1C | 0.2946 | 0.5864 | 1.4716 | 0.187* | |
C12 | −0.0554 (6) | 0.2116 (7) | 0.3942 (7) | 0.1387 (19) | |
H12 | −0.1072 | 0.2797 | 0.4372 | 0.166* |
U11 | U22 | U33 | U12 | U13 | U23 | |
S1 | 0.1349 (10) | 0.1084 (7) | 0.1140 (8) | 0.0544 (6) | 0.0875 (8) | 0.0726 (6) |
N1 | 0.127 (3) | 0.1003 (19) | 0.125 (3) | 0.0618 (18) | 0.091 (2) | 0.0806 (19) |
C7 | 0.089 (2) | 0.109 (3) | 0.094 (3) | 0.052 (2) | 0.059 (2) | 0.079 (2) |
C3 | 0.096 (3) | 0.103 (3) | 0.103 (3) | 0.063 (2) | 0.067 (2) | 0.081 (2) |
C2 | 0.095 (3) | 0.143 (3) | 0.108 (3) | 0.075 (2) | 0.074 (2) | 0.099 (3) |
O1 | 0.153 (3) | 0.129 (2) | 0.109 (2) | 0.071 (2) | 0.0761 (19) | 0.0827 (18) |
N2 | 0.136 (3) | 0.132 (3) | 0.093 (2) | 0.036 (2) | 0.059 (2) | 0.083 (2) |
C4 | 0.121 (3) | 0.112 (3) | 0.125 (3) | 0.080 (3) | 0.094 (3) | 0.095 (3) |
C6 | 0.089 (3) | 0.104 (3) | 0.099 (3) | 0.048 (2) | 0.055 (2) | 0.079 (2) |
C8 | 0.103 (3) | 0.110 (3) | 0.109 (3) | 0.065 (2) | 0.075 (2) | 0.079 (2) |
C9 | 0.094 (3) | 0.112 (2) | 0.087 (2) | 0.035 (2) | 0.046 (2) | 0.071 (2) |
C11 | 0.090 (3) | 0.113 (3) | 0.115 (3) | 0.045 (2) | 0.063 (3) | 0.080 (3) |
N3 | 0.125 (3) | 0.144 (3) | 0.103 (2) | 0.024 (2) | 0.056 (2) | 0.086 (2) |
C5 | 0.155 (4) | 0.122 (3) | 0.146 (4) | 0.062 (3) | 0.108 (3) | 0.096 (3) |
C16 | 0.089 (3) | 0.105 (3) | 0.106 (3) | 0.041 (2) | 0.032 (3) | 0.052 (3) |
C14 | 0.092 (4) | 0.168 (5) | 0.118 (4) | −0.010 (3) | 0.024 (3) | 0.093 (4) |
C10 | 0.156 (4) | 0.107 (3) | 0.128 (3) | 0.052 (3) | 0.089 (3) | 0.075 (3) |
C13 | 0.088 (4) | 0.253 (7) | 0.185 (6) | 0.062 (4) | 0.056 (4) | 0.169 (6) |
C15 | 0.114 (4) | 0.126 (3) | 0.112 (4) | 0.033 (3) | 0.049 (3) | 0.049 (3) |
C1 | 0.175 (4) | 0.189 (4) | 0.137 (3) | 0.123 (4) | 0.107 (3) | 0.137 (3) |
C12 | 0.124 (4) | 0.224 (5) | 0.191 (5) | 0.112 (4) | 0.109 (4) | 0.155 (5) |
S1—C8 | 1.752 (4) | C11—C10 | 1.497 (5) |
S1—C10 | 1.815 (4) | C5—H5A | 0.9600 |
N1—C8 | 1.336 (4) | C5—H5B | 0.9600 |
N1—C4 | 1.353 (4) | C5—H5C | 0.9600 |
C7—C8 | 1.395 (5) | C16—C15 | 1.383 (5) |
C7—C6 | 1.399 (4) | C16—H16 | 0.9300 |
C7—C9 | 1.425 (4) | C14—C15 | 1.341 (6) |
C3—C4 | 1.393 (5) | C14—C13 | 1.342 (7) |
C3—C6 | 1.423 (4) | C14—H14 | 0.9300 |
C3—C2 | 1.494 (5) | C10—H10A | 0.9700 |
C2—O1 | 1.203 (4) | C10—H10B | 0.9700 |
C2—C1 | 1.512 (4) | C13—C12 | 1.355 (7) |
N2—C6 | 1.338 (4) | C13—H13 | 0.9300 |
N2—H2A | 0.8600 | C15—H15 | 0.9300 |
N2—H2B | 0.8600 | C1—H1A | 0.9600 |
C4—C5 | 1.519 (4) | C1—H1B | 0.9600 |
C9—N3 | 1.136 (4) | C1—H1C | 0.9600 |
C11—C16 | 1.359 (5) | C12—H12 | 0.9300 |
C11—C12 | 1.376 (6) | ||
C8—S1—C10 | 101.86 (18) | C4—C5—H5C | 109.5 |
C8—N1—C4 | 117.3 (3) | H5A—C5—H5C | 109.5 |
C8—C7—C6 | 119.5 (3) | H5B—C5—H5C | 109.5 |
C8—C7—C9 | 119.5 (3) | C11—C16—C15 | 120.4 (4) |
C6—C7—C9 | 120.9 (3) | C11—C16—H16 | 119.8 |
C4—C3—C6 | 117.1 (3) | C15—C16—H16 | 119.8 |
C4—C3—C2 | 124.0 (3) | C15—C14—C13 | 120.4 (5) |
C6—C3—C2 | 118.8 (4) | C15—C14—H14 | 119.8 |
O1—C2—C3 | 120.7 (3) | C13—C14—H14 | 119.8 |
O1—C2—C1 | 119.2 (3) | C11—C10—S1 | 108.9 (2) |
C3—C2—C1 | 120.1 (4) | C11—C10—H10A | 109.9 |
C6—N2—H2A | 120.0 | S1—C10—H10A | 109.9 |
C6—N2—H2B | 120.0 | C11—C10—H10B | 109.9 |
H2A—N2—H2B | 120.0 | S1—C10—H10B | 109.9 |
N1—C4—C3 | 124.6 (3) | H10A—C10—H10B | 108.3 |
N1—C4—C5 | 111.0 (4) | C14—C13—C12 | 119.5 (5) |
C3—C4—C5 | 124.2 (3) | C14—C13—H13 | 120.3 |
N2—C6—C7 | 120.1 (3) | C12—C13—H13 | 120.3 |
N2—C6—C3 | 121.8 (3) | C14—C15—C16 | 120.3 (5) |
C7—C6—C3 | 118.1 (4) | C14—C15—H15 | 119.8 |
N1—C8—C7 | 123.0 (3) | C16—C15—H15 | 119.8 |
N1—C8—S1 | 118.5 (3) | C2—C1—H1A | 109.5 |
C7—C8—S1 | 118.4 (2) | C2—C1—H1B | 109.5 |
N3—C9—C7 | 179.0 (4) | H1A—C1—H1B | 109.5 |
C16—C11—C12 | 117.1 (4) | C2—C1—H1C | 109.5 |
C16—C11—C10 | 120.3 (4) | H1A—C1—H1C | 109.5 |
C12—C11—C10 | 122.6 (4) | H1B—C1—H1C | 109.5 |
C4—C5—H5A | 109.5 | C13—C12—C11 | 122.2 (5) |
C4—C5—H5B | 109.5 | C13—C12—H12 | 118.9 |
H5A—C5—H5B | 109.5 | C11—C12—H12 | 118.9 |
C4—C3—C2—O1 | −143.0 (4) | C4—N1—C8—S1 | 178.9 (2) |
C6—C3—C2—O1 | 38.4 (5) | C6—C7—C8—N1 | 0.8 (5) |
C4—C3—C2—C1 | 40.0 (5) | C9—C7—C8—N1 | −179.3 (3) |
C6—C3—C2—C1 | −138.5 (3) | C6—C7—C8—S1 | 177.6 (2) |
C8—N1—C4—C3 | 2.7 (5) | C9—C7—C8—S1 | −2.4 (4) |
C8—N1—C4—C5 | 178.6 (3) | C10—S1—C8—N1 | −1.9 (3) |
C6—C3—C4—N1 | 2.2 (5) | C10—S1—C8—C7 | −178.9 (3) |
C2—C3—C4—N1 | −176.4 (3) | C12—C11—C16—C15 | −1.0 (6) |
C6—C3—C4—C5 | −173.2 (3) | C10—C11—C16—C15 | 177.4 (4) |
C2—C3—C4—C5 | 8.3 (5) | C16—C11—C10—S1 | 100.1 (3) |
C8—C7—C6—N2 | −177.3 (3) | C12—C11—C10—S1 | −81.6 (4) |
C9—C7—C6—N2 | 2.8 (5) | C8—S1—C10—C11 | 171.6 (3) |
C8—C7—C6—C3 | 4.2 (5) | C15—C14—C13—C12 | −1.9 (8) |
C9—C7—C6—C3 | −175.7 (3) | C13—C14—C15—C16 | 2.2 (7) |
C4—C3—C6—N2 | 176.0 (3) | C11—C16—C15—C14 | −0.7 (6) |
C2—C3—C6—N2 | −5.4 (5) | C14—C13—C12—C11 | 0.2 (8) |
C4—C3—C6—C7 | −5.5 (4) | C16—C11—C12—C13 | 1.2 (7) |
C2—C3—C6—C7 | 173.1 (3) | C10—C11—C12—C13 | −177.1 (4) |
C4—N1—C8—C7 | −4.2 (5) |
D—H···A | D—H | H···A | D···A | D—H···A |
N2—H2B···O1 | 0.86 | 2.11 | 2.726 (3) | 129 |
N2—H2B···O1i | 0.86 | 2.34 | 3.105 (5) | 148 |
Symmetry code: (i) −x+1, −y+2, −z+3. |
Experimental details
Crystal data | |
Chemical formula | C16H15N3OS |
Mr | 297.37 |
Crystal system, space group | Triclinic, P1 |
Temperature (K) | 295 |
a, b, c (Å) | 8.6850 (5), 9.9127 (6), 10.3236 (7) |
α, β, γ (°) | 111.007 (1), 105.027 (1), 101.552 (1) |
V (Å3) | 757.78 (8) |
Z | 2 |
Radiation type | Mo Kα |
µ (mm−1) | 0.22 |
Crystal size (mm) | 0.16 × 0.10 × 0.10 |
Data collection | |
Diffractometer | Bruker SMART CCD area-detector |
Absorption correction | Multi-scan (SADABS; Bruker, 2000) |
Tmin, Tmax | 0.966, 0.979 |
No. of measured, independent and observed [I > 2σ(I)] reflections | 5133, 2621, 1413 |
Rint | 0.025 |
(sin θ/λ)max (Å−1) | 0.595 |
Refinement | |
R[F2 > 2σ(F2)], wR(F2), S | 0.063, 0.179, 0.99 |
No. of reflections | 2621 |
No. of parameters | 192 |
H-atom treatment | H-atom parameters constrained |
Δρmax, Δρmin (e Å−3) | 0.17, −0.16 |
Computer programs: SMART (Bruker, 2000), SAINT (Bruker, 2000), SAINT, SHELXS97 (Sheldrick, 1997), SHELXL97 (Sheldrick, 1997), SHELXTL (Bruker, 1997), SHELXTL.
D—H···A | D—H | H···A | D···A | D—H···A |
N2—H2B···O1 | 0.86 | 2.11 | 2.726 (3) | 128.6 |
N2—H2B···O1i | 0.86 | 2.34 | 3.105 (5) | 148.3 |
Symmetry code: (i) −x+1, −y+2, −z+3. |
Pyridine derivatives are important compounds in terms of pesticides and medicines (Bretschneider et al., 1999; Hirano 2000; Hui et al., 2000; Nicholas et al., 2000). We report here the molecular structure of the title compound (I).
In the title compound (I), all bond lengths and angles are within normal ranges (Allen et al., 1987) and the crystal structure are stabilized by intra and intermolecular hydrogen bonds (Table 1).