Structure of the LCMV nucleoprotein provides a template for understanding arenavirus replication and immunosuppression

West, B.R.; Hastie, K.M.; Saphire, E.O.

doi:10.1107/S1399004714007883

Structure of the LCMV nucleoprotein provides a template for understanding arenavirus replication and immunosuppression

B. R. West, K. M. Hastie and E. O. Saphire

The X-ray crystal structure of the Lymphocytic choriomeningitis virus nucleoprotein C-terminal immunosuppressive domain (LCMV NPΔ340) was determined to 2.0 Å resolution. The structure indicates that LCMV NPΔ340, like the other structurally characterized arenaviral nucleoproteins, adopts the fold of an exonuclease. This structure provides a crucial three-dimensional template for functional exploration of the replication and immunosuppression of this prototypic arenavirus.

Keywords: Lymphocytic choriomeningitis virus; nucleoprotein.

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Structure of the LCMV nucleoprotein provides a template for understanding arenavirus replication and immunosuppression

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