17,17-Ethylenedioxyandrost-4-ene-3,6-dione and 17,17-Ethylenedioxyandrosta-1,4-diene-3,6-dione

The crystal structures of 17, 17-ethylenedioxyandrost-4-ene-3,6-dione, C₂₁H₂₈O₄, and 17, 17-ethylenedioxyandrosta-1,4-diene-3,6-dione, C₂₁H₂₆O₄, intermediates in the synthesis of heteroandrogenic aromatase inhibitors, have been determined. Both structures are stabilized by C— H...O hydrogen bonds, highlighting the importance of weak interactions in influencing packing motifs in general and the conformation of the flexible dioxolane ring in particular.

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