Supporting information
Crystallographic Information File (CIF) https://doi.org/10.1107/S160053680301852X/om6161sup1.cif | |
Structure factor file (CIF format) https://doi.org/10.1107/S160053680301852X/om6161Isup2.hkl |
CCDC reference: 222905
To a mixture of N-(2-bromophenyl)-2-hydroxybenzylamine (4.29 g, 5.5 mmol) and potassium carbonate (12.96 g, 46.5 mmol) in tetrahydrofuran (THF; 100 ml), a solution of 2-methanesulfonyl- 4,6-dimethoxypyrimidine (7.50 g, 17.2 mmol) in THF (40 ml) was added dropwise and stirred for 11 h under reflux. The solid was filtered off and the filtrate was evaporated. A single-crystal suitable for X-ray analysis was obtained by recrystallization from ethanol solution. Upon slow evaporation at room temperature for 5 d, a colorless crystalline solid appeared and was collected by filtration.
H atoms were placed in calculated positions (C—H = 1.00 Å and N—H = 0.939 Å) and included in the final cycles of refinement as riding atoms.
Data collection: PROCESS-AUTO (Rigaku, 2003); cell refinement: PROCESS-AUTO; data reduction: CrystalStructure (Rigaku, 2003); program(s) used to solve structure: SHELXS97 (Sheldrick, 1997); program(s) used to refine structure: CRYSTALS (Watkin et al., 1996); molecular graphics: ORTEP-3 for Windows (Farrugia, 1997); software used to prepare material for publication: CrystalStructure.
Fig. 1. The molecular structure of (I), showing ellipsoids at the 30% probability level. |
C19H18BrN3O3 | Z = 2 |
Mr = 416.27 | F(000) = 424.00 |
Triclinic, P1 | Dx = 1.499 Mg m−3 |
Hall symbol: -P 1 | Mo Kα radiation, λ = 0.7107 Å |
a = 8.7821 (5) Å | Cell parameters from 3573 reflections |
b = 10.3347 (6) Å | θ = 2.1–27.4° |
c = 10.975 (1) Å | µ = 2.26 mm−1 |
α = 104.779 (5)° | T = 296 K |
β = 92.572 (2)° | Platelet, colorless |
γ = 105.331 (2)° | 0.36 × 0.21 × 0.07 mm |
V = 922.1 (1) Å3 |
Rigaku RAXIS-RAPID diffractometer | 2351 reflections with F2 > 2.0σ(F2) |
Detector resolution: 10.00 pixels mm-1 | Rint = 0.029 |
ω scans | θmax = 27.5° |
Absorption correction: multi-scan (ABSCOR; Higashi,1995) | h = −9→11 |
Tmin = 0.678, Tmax = 0.854 | k = −13→13 |
17152 measured reflections | l = −14→14 |
4157 independent reflections |
Refinement on F2 | H-atom parameters constrained |
R[F2 > 2σ(F2)] = 0.048 | w = 1/[0.002Fo2 + 1.35σ(Fo2)]/(4Fo2) |
wR(F2) = 0.130 | (Δ/σ)max = 0.0001 |
S = 1.01 | Δρmax = 0.97 e Å−3 |
2788 reflections | Δρmin = −0.67 e Å−3 |
253 parameters |
C19H18BrN3O3 | γ = 105.331 (2)° |
Mr = 416.27 | V = 922.1 (1) Å3 |
Triclinic, P1 | Z = 2 |
a = 8.7821 (5) Å | Mo Kα radiation |
b = 10.3347 (6) Å | µ = 2.26 mm−1 |
c = 10.975 (1) Å | T = 296 K |
α = 104.779 (5)° | 0.36 × 0.21 × 0.07 mm |
β = 92.572 (2)° |
Rigaku RAXIS-RAPID diffractometer | 4157 independent reflections |
Absorption correction: multi-scan (ABSCOR; Higashi,1995) | 2351 reflections with F2 > 2.0σ(F2) |
Tmin = 0.678, Tmax = 0.854 | Rint = 0.029 |
17152 measured reflections |
R[F2 > 2σ(F2)] = 0.048 | 253 parameters |
wR(F2) = 0.130 | H-atom parameters constrained |
S = 1.01 | Δρmax = 0.97 e Å−3 |
2788 reflections | Δρmin = −0.67 e Å−3 |
Geometry. ENTER SPECIAL DETAILS OF THE MOLECULAR GEOMETRY |
Refinement. Refinement of F2 against ALL reflections. The weighted R-factor wR and goodness of fit S are based on F2, conventional R-factors R are based on F, with F set to zero for negative F2. The threshold expression of F2 > σ(F2) is used only for calculating R-factors(gt) etc. and is not relevant to the choice of reflections for refinement. R-factors based on F2 are statistically about twice as large as those based on F, and R- factors based on ALL data will be even larger. |
x | y | z | Uiso*/Ueq | ||
Br(1) | 0.51346 (7) | −0.03208 (5) | 0.29600 (6) | 0.0805 (2) | |
O(1) | 0.3026 (3) | 0.4381 (2) | −0.0331 (3) | 0.0434 (7) | |
O(2) | 0.1436 (3) | 0.1535 (3) | −0.4310 (3) | 0.0524 (9) | |
O(3) | −0.1442 (3) | 0.0659 (3) | −0.0984 (3) | 0.0511 (8) | |
N(1) | 0.4486 (4) | 0.2015 (3) | 0.1958 (3) | 0.0453 (9) | |
N(2) | 0.2240 (4) | 0.2997 (3) | −0.2293 (3) | 0.0398 (9) | |
N(3) | 0.0771 (3) | 0.2555 (3) | −0.0594 (3) | 0.0365 (8) | |
C(1) | 0.6000 (4) | 0.2376 (3) | 0.2557 (3) | 0.035 (1) | |
C(2) | 0.6522 (5) | 0.1475 (4) | 0.3121 (4) | 0.043 (1) | |
C(3) | 0.8043 (5) | 0.1810 (5) | 0.3721 (4) | 0.056 (1) | |
C(4) | 0.9089 (5) | 0.3069 (5) | 0.3774 (5) | 0.063 (1) | |
C(5) | 0.8630 (5) | 0.3991 (4) | 0.3252 (4) | 0.056 (1) | |
C(6) | 0.7105 (5) | 0.3664 (4) | 0.2654 (4) | 0.044 (1) | |
C(7) | 0.4026 (5) | 0.2749 (4) | 0.1092 (4) | 0.045 (1) | |
C(8) | 0.3502 (4) | 0.4016 (3) | 0.1732 (4) | 0.034 (1) | |
C(9) | 0.2941 (4) | 0.4743 (3) | 0.0984 (4) | 0.037 (1) | |
C(10) | 0.2439 (5) | 0.5894 (4) | 0.1510 (5) | 0.052 (1) | |
C(11) | 0.2493 (5) | 0.6348 (4) | 0.2800 (5) | 0.054 (1) | |
C(12) | 0.3049 (5) | 0.5664 (4) | 0.3564 (4) | 0.048 (1) | |
C(13) | 0.3547 (4) | 0.4513 (4) | 0.3024 (4) | 0.043 (1) | |
C(14) | 0.1935 (4) | 0.3243 (3) | −0.1103 (4) | 0.037 (1) | |
C(15) | 0.1204 (4) | 0.1869 (4) | −0.3081 (4) | 0.039 (1) | |
C(16) | −0.0061 (4) | 0.1044 (4) | −0.2689 (4) | 0.045 (1) | |
C(17) | −0.0232 (4) | 0.1429 (4) | −0.1429 (4) | 0.038 (1) | |
C(18) | 0.2807 (6) | 0.2364 (5) | −0.4681 (4) | 0.059 (1) | |
C(19) | −0.1643 (6) | 0.1100 (5) | 0.0314 (5) | 0.067 (2) | |
H(1) | 0.8376 | 0.1135 | 0.4108 | 0.069* | |
H(2) | 1.0197 | 0.3320 | 0.4204 | 0.069* | |
H(3) | 0.9405 | 0.4911 | 0.3300 | 0.063* | |
H(4) | 0.6781 | 0.4349 | 0.2277 | 0.050* | |
H(5) | 0.3917 | 0.1127 | 0.2010 | 0.054* | |
H(6) | 0.4969 | 0.3072 | 0.0653 | 0.054* | |
H(7) | 0.3137 | 0.2080 | 0.0450 | 0.054* | |
H(8) | 0.2029 | 0.6387 | 0.0953 | 0.063* | |
H(9) | 0.2123 | 0.7181 | 0.3187 | 0.063* | |
H(10) | 0.3107 | 0.6010 | 0.4508 | 0.054* | |
H(11) | 0.3946 | 0.4019 | 0.3586 | 0.051* | |
H(12) | −0.0819 | 0.0204 | −0.3295 | 0.050* | |
H(13) | 0.3789 | 0.2335 | −0.4204 | 0.071* | |
H(14) | 0.2836 | 0.1996 | −0.5613 | 0.071* | |
H(15) | 0.2754 | 0.3349 | −0.4487 | 0.071* | |
H(16) | −0.0664 | 0.1157 | 0.0851 | 0.074* | |
H(17) | −0.1826 | 0.2042 | 0.0498 | 0.074* | |
H(18) | −0.2578 | 0.0422 | 0.0509 | 0.074* |
U11 | U22 | U33 | U12 | U13 | U23 | |
Br(1) | 0.0822 (4) | 0.0505 (3) | 0.1143 (6) | 0.0123 (2) | −0.0103 (3) | 0.0430 (3) |
O(1) | 0.048 (2) | 0.037 (1) | 0.037 (2) | −0.004 (1) | −0.009 (1) | 0.015 (1) |
O(2) | 0.057 (2) | 0.052 (2) | 0.038 (2) | 0.003 (1) | 0.005 (1) | 0.008 (1) |
O(3) | 0.042 (2) | 0.047 (1) | 0.048 (2) | −0.005 (1) | 0.008 (1) | 0.002 (1) |
N(1) | 0.045 (2) | 0.033 (2) | 0.056 (2) | 0.005 (1) | −0.013 (2) | 0.018 (1) |
N(2) | 0.045 (2) | 0.035 (2) | 0.038 (2) | 0.006 (1) | −0.004 (2) | 0.014 (1) |
N(3) | 0.035 (2) | 0.035 (1) | 0.036 (2) | 0.006 (1) | −0.002 (1) | 0.011 (1) |
C(1) | 0.037 (2) | 0.036 (2) | 0.032 (2) | 0.011 (1) | 0.003 (2) | 0.008 (1) |
C(2) | 0.048 (2) | 0.038 (2) | 0.043 (3) | 0.016 (2) | 0.002 (2) | 0.011 (2) |
C(3) | 0.058 (3) | 0.064 (3) | 0.050 (3) | 0.034 (2) | −0.007 (2) | 0.007 (2) |
C(4) | 0.037 (2) | 0.073 (3) | 0.064 (3) | 0.016 (2) | −0.008 (2) | −0.007 (2) |
C(5) | 0.050 (3) | 0.047 (2) | 0.060 (3) | 0.007 (2) | 0.007 (2) | 0.001 (2) |
C(6) | 0.048 (2) | 0.034 (2) | 0.045 (3) | 0.006 (2) | 0.005 (2) | 0.007 (2) |
C(7) | 0.056 (2) | 0.037 (2) | 0.042 (2) | 0.017 (2) | −0.010 (2) | 0.008 (2) |
C(8) | 0.034 (2) | 0.029 (2) | 0.036 (2) | 0.004 (1) | −0.001 (2) | 0.010 (1) |
C(9) | 0.037 (2) | 0.030 (2) | 0.036 (2) | −0.000 (1) | −0.006 (2) | 0.009 (1) |
C(10) | 0.052 (2) | 0.035 (2) | 0.070 (3) | 0.010 (2) | −0.002 (2) | 0.022 (2) |
C(11) | 0.050 (3) | 0.037 (2) | 0.070 (3) | 0.013 (2) | 0.012 (2) | 0.005 (2) |
C(12) | 0.040 (2) | 0.054 (2) | 0.041 (3) | 0.006 (2) | 0.006 (2) | 0.002 (2) |
C(13) | 0.040 (2) | 0.048 (2) | 0.038 (3) | 0.008 (2) | 0.003 (2) | 0.015 (2) |
C(14) | 0.040 (2) | 0.030 (2) | 0.040 (3) | 0.007 (1) | −0.009 (2) | 0.014 (2) |
C(15) | 0.044 (2) | 0.038 (2) | 0.036 (3) | 0.015 (2) | −0.001 (2) | 0.009 (2) |
C(16) | 0.042 (2) | 0.039 (2) | 0.044 (3) | 0.003 (2) | −0.002 (2) | 0.005 (2) |
C(17) | 0.028 (2) | 0.037 (2) | 0.046 (3) | 0.008 (1) | −0.001 (2) | 0.011 (2) |
C(18) | 0.074 (3) | 0.059 (3) | 0.046 (3) | 0.011 (2) | 0.017 (2) | 0.020 (2) |
C(19) | 0.070 (3) | 0.056 (3) | 0.060 (3) | 0.000 (2) | 0.026 (3) | 0.006 (2) |
Br(1)—C(2) | 1.891 (3) | C(6)—H(4) | 1.000 |
O(1)—C(9) | 1.406 (5) | C(7)—C(8) | 1.516 (5) |
O(1)—C(14) | 1.357 (3) | C(7)—H(6) | 1.000 |
O(2)—C(15) | 1.343 (5) | C(7)—H(7) | 1.000 |
O(2)—C(18) | 1.423 (5) | C(8)—C(9) | 1.397 (6) |
O(3)—C(17) | 1.342 (5) | C(8)—C(13) | 1.375 (5) |
O(3)—C(19) | 1.415 (6) | C(9)—C(10) | 1.376 (5) |
N(1)—C(1) | 1.368 (5) | C(10)—C(11) | 1.367 (7) |
N(1)—C(7) | 1.463 (6) | C(10)—H(8) | 1.000 |
N(1)—H(5) | 0.939 | C(11)—C(12) | 1.375 (7) |
N(2)—C(14) | 1.319 (5) | C(11)—H(9) | 1.000 |
N(2)—C(15) | 1.337 (4) | C(12)—C(13) | 1.377 (6) |
N(3)—C(14) | 1.316 (5) | C(12)—H(10) | 1.000 |
N(3)—C(17) | 1.346 (4) | C(13)—H(11) | 1.000 |
C(1)—C(2) | 1.399 (6) | C(15)—C(16) | 1.369 (5) |
C(1)—C(6) | 1.400 (5) | C(16)—C(17) | 1.364 (6) |
C(2)—C(3) | 1.377 (6) | C(16)—H(12) | 1.000 |
C(3)—C(4) | 1.366 (6) | C(18)—H(13) | 1.000 |
C(3)—H(1) | 1.000 | C(18)—H(14) | 1.000 |
C(4)—C(5) | 1.363 (8) | C(18)—H(15) | 1.000 |
C(4)—H(2) | 1.000 | C(19)—H(16) | 1.000 |
C(5)—C(6) | 1.381 (6) | C(19)—H(17) | 1.000 |
C(5)—H(3) | 1.000 | C(19)—H(18) | 1.000 |
C(9)—O(1)—C(14) | 119.7 (3) | O(1)—C(9)—C(8) | 119.7 (3) |
C(15)—O(2)—C(18) | 118.0 (3) | C(11)—C(10)—H(8) | 120.4 |
C(17)—O(3)—C(19) | 118.8 (3) | C(11)—C(10)—C(9) | 119.4 (5) |
C(1)—N(1)—C(7) | 122.5 (3) | H(8)—C(10)—C(9) | 120.2) |
C(1)—N(1)—H(5) | 110.0 | C(12)—C(11)—H(9) | 120.0 |
C(7)—N(1)—H(5) | 125.6 | C(12)—C(11)—C(10) | 120.3 (4) |
C(14)—N(2)—C(15) | 114.0 (3) | H(9)—C(11)—C(10) | 119.7 |
C(14)—N(3)—C(17) | 113.8 (3) | C(13)—C(12)—H(10) | 120.2 |
C(2)—C(1)—C(6) | 116.2 (3) | C(13)—C(12)—C(11) | 119.7 (4) |
C(2)—C(1)—N(1) | 121.4 (3) | H(10)—C(12)—C(11) | 120.1 |
C(6)—C(1)—N(1) | 122.4 (4) | H(11)—C(13)—C(8) | 118.9 |
C(3)—C(2)—Br(1) | 118.6 (3) | H(11)—C(13)—C(12) | 119.2 |
C(3)—C(2)—C(1) | 122.5 (3) | C(8)—C(13)—C(12) | 121.9 (4) |
Br(1)—C(2)—C(1) | 118.8 (3) | O(1)—C(14)—N(2) | 112.2 (3) |
C(4)—C(3)—H(1) | 120.6 | O(1)—C(14)—N(3) | 118.2 (3) |
C(4)—C(3)—C(2) | 119.2 (5) | N(2)—C(14)—N(3) | 129.7 (3) |
H(1)—C(3)—C(2) | 120.3 | C(16)—C(15)—O(2) | 119.1 (3) |
C(5)—C(4)—H(2) | 119.7 | C(16)—C(15)—N(2) | 123.1 (4) |
C(5)—C(4)—C(3) | 120.5 (4) | O(2)—C(15)—N(2) | 117.9 (3) |
H(2)—C(4)—C(3) | 119.8 | C(17)—C(16)—H(12) | 121.8 |
C(6)—C(5)—H(3) | 119.6 | C(17)—C(16)—C(15) | 116.5 (3) |
C(6)—C(5)—C(4) | 120.6 (4) | H(12)—C(16)—C(15) | 121.7 |
H(3)—C(5)—C(4) | 119.8 | O(3)—C(17)—N(3) | 117.6 (3) |
H(4)—C(6)—C(1) | 119.1 | O(3)—C(17)—C(16) | 119.4 (3) |
H(4)—C(6)—C(5) | 119.9 | N(3)—C(17)—C(16) | 123.0 (3) |
C(1)—C(6)—C(5) | 121.0 (4) | H(13)—C(18)—H(14) | 109.5 |
C(8)—C(7)—H(6) | 107.8 | H(13)—C(18)—H(15) | 109.5 |
C(8)—C(7)—H(7) | 108.7 | H(13)—C(18)—O(2) | 109.9 |
C(8)—C(7)—N(1) | 114.5 (3) | H(14)—C(18)—H(15) | 109.5 |
H(6)—C(7)—H(7) | 109.5 | H(14)—C(18)—O(2) | 109.6 |
H(6)—C(7)—N(1) | 107.7 | H(15)—C(18)—O(2) | 109.0 |
H(7)—C(7)—N(1) | 108.6 | H(16)—C(19)—H(17) | 109.5 |
C(9)—C(8)—C(13) | 116.9 (3) | H(16)—C(19)—H(18) | 109.5 |
C(9)—C(8)—C(7) | 119.2 (3) | H(16)—C(19)—O(3) | 109.6 |
C(13)—C(8)—C(7) | 123.9 (4) | H(17)—C(19)—H(18) | 109.5 |
C(10)—C(9)—O(1) | 118.3 (4) | H(17)—C(19)—O(3) | 109.0 |
C(10)—C(9)—C(8) | 121.8 (4) | H(18)—C(19)—O(3) | 109.9 |
Experimental details
Crystal data | |
Chemical formula | C19H18BrN3O3 |
Mr | 416.27 |
Crystal system, space group | Triclinic, P1 |
Temperature (K) | 296 |
a, b, c (Å) | 8.7821 (5), 10.3347 (6), 10.975 (1) |
α, β, γ (°) | 104.779 (5), 92.572 (2), 105.331 (2) |
V (Å3) | 922.1 (1) |
Z | 2 |
Radiation type | Mo Kα |
µ (mm−1) | 2.26 |
Crystal size (mm) | 0.36 × 0.21 × 0.07 |
Data collection | |
Diffractometer | Rigaku RAXIS-RAPID diffractometer |
Absorption correction | Multi-scan (ABSCOR; Higashi,1995) |
Tmin, Tmax | 0.678, 0.854 |
No. of measured, independent and observed [F2 > 2.0σ(F2)] reflections | 17152, 4157, 2351 |
Rint | 0.029 |
(sin θ/λ)max (Å−1) | 0.649 |
Refinement | |
R[F2 > 2σ(F2)], wR(F2), S | 0.048, 0.130, 1.01 |
No. of reflections | 2788 |
No. of parameters | 253 |
No. of restraints | ? |
H-atom treatment | H-atom parameters constrained |
Δρmax, Δρmin (e Å−3) | 0.97, −0.67 |
Computer programs: PROCESS-AUTO (Rigaku, 2003), PROCESS-AUTO, CrystalStructure (Rigaku, 2003), SHELXS97 (Sheldrick, 1997), CRYSTALS (Watkin et al., 1996), ORTEP-3 for Windows (Farrugia, 1997), CrystalStructure.
C(9)—O(1)—C(14) | 119.7 (3) | C(9)—C(8)—C(13) | 116.9 (3) |
C(1)—N(1)—C(7) | 122.5 (3) | N(2)—C(14)—N(3) | 129.7 (3) |
C(2)—C(1)—C(6) | 116.2 (3) |
4,6-Dimethoxypyrimidines with a phenoxy substituent at the 2-position exhibit marked herbicidal activity (Nezu et al., 1996; Tamaru et al., 1997; Hudson et al., 2002). The new title compound, (I), has shown herbicidal activity against various grass and broadleaf weeds. The present X-ray crystal structure analysis was undertaken in order to improve our understanding of the relationship between structure and activity.
The bond lengths and angles in the pyrimidine moiety are close to those found in related compounds (Hall et al., 1999; Lin et al., 2001), but the N2—C14—N3 angle [129.7 (3)°] deviates significantly from the normal value. The angles in the two benzene rings are close to 120° (Huo et al., 1995), except for the C9—C8—C13 and C2—C1—C6 angles [116.9 (3) and 116.2 (3)°, respectively; Table 1).
The fact that the C9—O1—C14 angle is 119.7 (3)° shows the influence of the pyrimidine and benzene ring on the ether angle (Takashima et al., 1999). The widening of the C1—N1—C7 angle [to 122.5 (3)°] from 108° may be due to steric interaction. The N1—C1 bond distance [1.368 (5) Å] is close to that of a C═N double bond and is probably caused by delocalization of benzene electrons (Table 1).
There is one intramolecular hydrogen bond [N1···Br1=3.065 (3) Å and N1—H5···Br1=122.43°]. The dihedral angles between the pyrimidine plane and the two benzene rings are 107.85 (4) and 77.38 (2)°, and the dihedral angle between the two benzene rings is 103.15 (3)°