Three Isostructural Furosemide Prodrugs

The structures of three furosemide prodrugs, pivaloyloxymethyl 4-chloro-N-furfuryl-5-sulfamoylanthranilate, C₁₈H₂₁ClN₂O₇S, butyryloxymethyl 4-chloro-N-furfuryl-5-sulfamoylanthranilate, C₁₇H₁₉ClN₂O₇S, and isobutyryloxymethyl 4-chloro-N-furfuryl-5-sulfamoylanthranilate, C₁₇H₁₉ClN₂O₇S, have been determined; the crystals have been shown to be isostructural. The crystal structures are described and compared with that of a related prodrug. The dihedral angle between the two planar rings of each prodrug is close to 70°. The space group is P in each case, and the molecules pack as dimers in infinite chains along one of the crystallographic axes.

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