An ABC-ring Analogue of Paclitaxel (Taxol^TM)

The X-ray crystal structure determination of the title compound (C₂₀H₂₂BrNO₅, systematic name methyl 14-bromo-6-methoxy-1,3-dioxo-2,3,3a,9,10,11,12,13,13a,13b-decahydro-1H-8,12-methanocyclodeca[e]isoindol-12-yl acetate), an ABC-ring analogue of the diterpene paclitaxel reveals that the stereochemical relationships between C(3), C(4) and C(5) (C13a, C13b and C3a, respectively, by systematic numbering) are the same as observed in the natural product.

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