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Supporting information
![]() | Crystallographic Information File (CIF) https://doi.org/10.1107/S2056989022011239/vm2274sup1.cif |
![]() | Structure factor file (CIF format) https://doi.org/10.1107/S2056989022011239/vm2274Isup2.hkl |
![]() | Structure factor file (CIF format) https://doi.org/10.1107/S2056989022011239/vm2274IIsup3.hkl |
![]() | Structure factor file (CIF format) https://doi.org/10.1107/S2056989022011239/vm2274IIIsup4.hkl |
![]() | Portable Network Graphics (PNG) image https://doi.org/10.1107/S2056989022011239/vm2274sup5.png |
![]() | Portable Network Graphics (PNG) image https://doi.org/10.1107/S2056989022011239/vm2274sup6.png |
![]() | Portable Network Graphics (PNG) image https://doi.org/10.1107/S2056989022011239/vm2274sup7.png |
CCDC references: 2221478; 2221477; 2221476
For all structures, data collection: APEX3 (Bruker, 2016); cell refinement: APEX3 (Bruker, 2016); data reduction: APEX3 (Bruker, 2016); program(s) used to solve structure: SHELXT (Sheldrick, 2015a); program(s) used to refine structure: SHELXL2019/2 (Sheldrick, 2015b); molecular graphics: XP in SHELXTL (Sheldrick, 2008); software used to prepare material for publication: SHELXTL (Sheldrick, 2008) and publCIF (Westrip, 2010).
C19H23F2N4O3+·C7H4NO4−·2H2O | Z = 2 |
Mr = 595.56 | F(000) = 624 |
Triclinic, P1 | Dx = 1.459 Mg m−3 |
a = 7.5736 (4) Å | Mo Kα radiation, λ = 0.71073 Å |
b = 13.1809 (9) Å | Cell parameters from 9803 reflections |
c = 13.8947 (9) Å | θ = 2.8–27.5° |
α = 85.658 (2)° | µ = 0.12 mm−1 |
β = 82.316 (2)° | T = 250 K |
γ = 81.108 (2)° | Cut block, yellow |
V = 1355.94 (15) Å3 | 0.33 × 0.31 × 0.27 mm |
Bruker D8 Venture dual source diffractometer | 6210 independent reflections |
Radiation source: microsource | 4944 reflections with I > 2σ(I) |
Detector resolution: 7.41 pixels mm-1 | Rint = 0.033 |
φ and ω scans | θmax = 27.6°, θmin = 2.2° |
Absorption correction: multi-scan (SADABS; Krause et al., 2015) | h = −9→9 |
Tmin = 0.930, Tmax = 0.971 | k = −17→17 |
45287 measured reflections | l = −17→18 |
Refinement on F2 | Primary atom site location: structure-invariant direct methods |
Least-squares matrix: full | Secondary atom site location: difference Fourier map |
R[F2 > 2σ(F2)] = 0.039 | Hydrogen site location: mixed |
wR(F2) = 0.107 | H atoms treated by a mixture of independent and constrained refinement |
S = 1.04 | w = 1/[σ2(Fo2) + (0.0419P)2 + 0.4829P] where P = (Fo2 + 2Fc2)/3 |
6210 reflections | (Δ/σ)max = 0.001 |
443 parameters | Δρmax = 0.27 e Å−3 |
46 restraints | Δρmin = −0.22 e Å−3 |
Experimental. The crystal was mounted using polyisobutene oil on the tip of a fine glass fibre, which was fastened in a copper mounting pin with electrical solder. It was placed directly into the cold gas stream of a liquid-nitrogen based cryostat (Hope, 1994; Parkin & Hope, 1998). The crystals appeared to become modulated (doubled cell, some satellite reflections) when cooled to 90K. Visual inspection of crystal integrity and diffraction quality vs temperature established a safe temperature for data collection of -23° C. |
Geometry. All esds (except the esd in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell esds are taken into account individually in the estimation of esds in distances, angles and torsion angles; correlations between esds in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell esds is used for estimating esds involving l.s. planes. |
Refinement. Refinement progress was checked using Platon (Spek, 2020) and by an R-tensor (Parkin, 2000). The final model was further checked with the IUCr utility checkCIF. |
x | y | z | Uiso*/Ueq | Occ. (<1) | |
O1W | 1.0080 (5) | 0.43691 (14) | 0.13115 (13) | 0.0767 (9) | 0.688 (3) |
H1W1 | 0.989672 | 0.457266 | 0.185755 | 0.115* | 0.688 (3) |
H2W1 | 1.079647 | 0.467749 | 0.098119 | 0.115* | 0.688 (3) |
O1W' | 0.8676 (14) | 0.4128 (5) | 0.1178 (6) | 0.070 (3) | 0.185 (3) |
H5W1 | 0.868139 | 0.425647 | 0.174506 | 0.105* | 0.185 (3) |
H6W1 | 0.860698 | 0.433812 | 0.056840 | 0.105* | 0.185 (3) |
O2W | 0.7704 (6) | 0.4430 (2) | −0.0090 (2) | 0.0987 (12) | 0.607 (3) |
H1W2 | 0.795334 | 0.431906 | 0.047015 | 0.148* | 0.607 (3) |
H2W2 | 0.794277 | 0.387475 | −0.034142 | 0.148* | 0.607 (3) |
O2W' | 0.6241 (18) | 0.4587 (10) | 0.0029 (7) | 0.148 (4) | 0.265 (3) |
H3W2 | 0.591257 | 0.540477 | −0.008066 | 0.222* | 0.265 (3) |
H4W2 | 0.611625 | 0.429007 | 0.056105 | 0.222* | 0.265 (3) |
O1W" | 1.1155 (10) | 0.5163 (6) | 0.1538 (6) | 0.035 (2) | 0.127 (2) |
H3W1 | 1.079941 | 0.501309 | 0.210951 | 0.053* | 0.127 (2) |
H4W1 | 1.058065 | 0.486154 | 0.122076 | 0.053* | 0.127 (2) |
O2W" | 0.4728 (18) | 0.3998 (9) | 0.0386 (7) | 0.071 (4) | 0.128 (3) |
H5W2 | 0.458449 | 0.355478 | 0.002884 | 0.107* | 0.128 (3) |
H6W2 | 0.421442 | 0.383063 | 0.092059 | 0.107* | 0.128 (3) |
F1 | 0.52757 (11) | 0.05643 (6) | 0.77813 (6) | 0.0371 (2) | |
F2 | 0.18695 (13) | 0.33665 (6) | 0.93914 (6) | 0.0439 (2) | |
O1 | 0.17039 (17) | −0.28135 (8) | 1.13520 (8) | 0.0491 (3) | |
O2 | 0.04706 (18) | −0.15414 (10) | 1.22784 (8) | 0.0531 (3) | |
H2O | 0.038 (3) | −0.080 (2) | 1.2189 (18) | 0.092 (8)* | |
O3 | 0.05728 (15) | 0.02882 (8) | 1.16122 (7) | 0.0410 (2) | |
N1 | 0.36989 (15) | −0.08370 (8) | 0.91686 (8) | 0.0278 (2) | |
N2 | 0.06988 (19) | 0.21803 (10) | 1.08748 (9) | 0.0408 (3) | |
H2NA | 0.054 (3) | 0.2860 (17) | 1.0912 (15) | 0.068 (6)* | |
H2NB | 0.028 (3) | 0.1740 (15) | 1.1371 (14) | 0.056 (5)* | |
N3 | 0.42835 (16) | 0.25859 (8) | 0.77468 (8) | 0.0312 (2) | |
N4 | 0.53893 (17) | 0.38569 (8) | 0.61030 (8) | 0.0302 (2) | |
H4NA | 0.627 (2) | 0.4111 (13) | 0.5620 (13) | 0.047 (5)* | |
H4NB | 0.433 (2) | 0.4245 (13) | 0.5980 (12) | 0.045 (5)* | |
C1 | 0.30722 (18) | −0.14548 (10) | 0.99045 (9) | 0.0299 (3) | |
H1 | 0.337777 | −0.216882 | 0.985064 | 0.036* | |
C2 | 0.20213 (18) | −0.11166 (10) | 1.07257 (9) | 0.0304 (3) | |
C3 | 0.15347 (17) | −0.00419 (10) | 1.08473 (9) | 0.0292 (3) | |
C4 | 0.22010 (17) | 0.06439 (10) | 1.00629 (9) | 0.0266 (3) | |
C5 | 0.33138 (16) | 0.02359 (9) | 0.92265 (9) | 0.0250 (2) | |
C6 | 0.40038 (17) | 0.0912 (1) | 0.85124 (9) | 0.0269 (3) | |
C7 | 0.35467 (17) | 0.1980 (1) | 0.85219 (9) | 0.0275 (3) | |
C8 | 0.24335 (18) | 0.23468 (10) | 0.93348 (10) | 0.0305 (3) | |
C9 | 0.17783 (18) | 0.17274 (10) | 1.01162 (9) | 0.0292 (3) | |
C10 | 0.38665 (19) | 0.24164 (10) | 0.67695 (9) | 0.0313 (3) | |
H10A | 0.270121 | 0.281690 | 0.666003 | 0.038* | |
H10B | 0.378584 | 0.168737 | 0.672166 | 0.038* | |
C11 | 0.53265 (18) | 0.27401 (9) | 0.60029 (9) | 0.0297 (3) | |
H11 | 0.649781 | 0.234195 | 0.613369 | 0.036* | |
C12 | 0.5777 (2) | 0.40582 (10) | 0.71004 (10) | 0.0333 (3) | |
H12 | 0.697490 | 0.367927 | 0.720892 | 0.040* | |
C13 | 0.4360 (2) | 0.36726 (10) | 0.78632 (10) | 0.0336 (3) | |
H13A | 0.465625 | 0.375773 | 0.851484 | 0.040* | |
H13B | 0.318020 | 0.407835 | 0.779453 | 0.040* | |
C14 | 0.5807 (3) | 0.51991 (11) | 0.71586 (12) | 0.0502 (4) | |
H14A | 0.608301 | 0.532920 | 0.779579 | 0.075* | |
H14B | 0.463712 | 0.557707 | 0.705381 | 0.075* | |
H14C | 0.671827 | 0.542109 | 0.666327 | 0.075* | |
C15 | 0.5023 (2) | 0.25721 (12) | 0.49722 (10) | 0.0389 (3) | |
H15A | 0.498785 | 0.184777 | 0.490906 | 0.058* | |
H15B | 0.599751 | 0.279189 | 0.451824 | 0.058* | |
H15C | 0.388849 | 0.296912 | 0.483088 | 0.058* | |
C16 | 0.4737 (2) | −0.12999 (10) | 0.83077 (10) | 0.0334 (3) | |
H16 | 0.603900 | −0.124621 | 0.821780 | 0.040* | |
C17 | 0.3878 (2) | −0.12486 (13) | 0.73970 (11) | 0.0475 (4) | |
H17A | 0.262288 | −0.091945 | 0.741442 | 0.057* | |
H17B | 0.463252 | −0.114810 | 0.677711 | 0.057* | |
C18 | 0.4245 (3) | −0.22495 (13) | 0.79618 (13) | 0.0575 (5) | |
H18A | 0.321508 | −0.253376 | 0.832512 | 0.069* | |
H18B | 0.522463 | −0.276239 | 0.768785 | 0.069* | |
C19 | 0.1399 (2) | −0.18977 (11) | 1.14682 (10) | 0.0378 (3) | |
O4 | 0.75064 (14) | 0.48408 (8) | 0.46618 (8) | 0.0416 (3) | |
O5 | 0.9197 (2) | 0.49587 (10) | 0.32356 (9) | 0.0704 (4) | |
O6 | 1.2405 (3) | −0.02164 (11) | 0.40432 (12) | 0.0886 (5) | |
O7 | 1.2235 (3) | 0.00344 (12) | 0.55450 (12) | 0.0933 (6) | |
N5 | 1.20030 (19) | 0.03305 (10) | 0.47204 (11) | 0.0486 (3) | |
C20 | 1.11515 (19) | 0.13962 (10) | 0.45442 (11) | 0.0349 (3) | |
C21 | 1.1012 (2) | 0.17648 (12) | 0.35967 (11) | 0.0441 (4) | |
H21 | 1.140867 | 0.133723 | 0.307551 | 0.053* | |
C22 | 1.0273 (2) | 0.27779 (12) | 0.34355 (11) | 0.0431 (4) | |
H22 | 1.018655 | 0.304761 | 0.279485 | 0.052* | |
C23 | 0.96571 (18) | 0.34046 (11) | 0.42053 (10) | 0.0328 (3) | |
C24 | 0.98225 (19) | 0.30048 (11) | 0.51504 (10) | 0.0338 (3) | |
H24 | 0.942055 | 0.342696 | 0.567518 | 0.041* | |
C25 | 1.05718 (19) | 0.19935 (11) | 0.53262 (10) | 0.0355 (3) | |
H25 | 1.068158 | 0.172163 | 0.596423 | 0.043* | |
C26 | 0.8742 (2) | 0.44884 (11) | 0.40125 (11) | 0.0384 (3) |
U11 | U22 | U33 | U12 | U13 | U23 | |
O1W | 0.150 (3) | 0.0352 (10) | 0.035 (1) | 0.0000 (13) | 0.0110 (12) | −0.0034 (7) |
O1W' | 0.089 (6) | 0.032 (4) | 0.074 (5) | 0.014 (4) | 0.023 (5) | −0.007 (3) |
O2W | 0.138 (3) | 0.0614 (17) | 0.093 (2) | 0.0114 (19) | −0.015 (2) | −0.0300 (15) |
O2W' | 0.152 (9) | 0.198 (11) | 0.103 (6) | −0.014 (9) | −0.021 (7) | −0.076 (7) |
O1W" | 0.035 (4) | 0.035 (4) | 0.034 (4) | −0.003 (3) | −0.005 (3) | 0.009 (3) |
O2W" | 0.107 (10) | 0.067 (7) | 0.043 (6) | −0.021 (7) | −0.003 (6) | −0.022 (5) |
F1 | 0.0448 (5) | 0.0298 (4) | 0.0315 (4) | −0.0027 (3) | 0.0113 (3) | −0.0035 (3) |
F2 | 0.0602 (6) | 0.0226 (4) | 0.0418 (5) | 0.0027 (4) | 0.0092 (4) | −0.0022 (3) |
O1 | 0.0692 (8) | 0.0342 (6) | 0.0456 (6) | −0.0145 (5) | −0.0130 (6) | 0.0113 (5) |
O2 | 0.0740 (8) | 0.0489 (7) | 0.0341 (6) | −0.0190 (6) | 0.0073 (5) | 0.0082 (5) |
O3 | 0.0515 (6) | 0.0395 (6) | 0.0280 (5) | −0.0064 (5) | 0.0082 (4) | −0.0004 (4) |
N1 | 0.0335 (6) | 0.0228 (5) | 0.0262 (5) | −0.0020 (4) | −0.0033 (4) | −0.0010 (4) |
N2 | 0.0544 (8) | 0.0304 (7) | 0.0321 (6) | −0.0001 (6) | 0.0092 (6) | −0.0048 (5) |
N3 | 0.0459 (7) | 0.0243 (5) | 0.0237 (5) | −0.0093 (5) | −0.0011 (5) | 0.0003 (4) |
N4 | 0.0354 (6) | 0.0231 (5) | 0.0296 (6) | −0.0018 (5) | 0.0000 (5) | 0.0031 (4) |
C1 | 0.0362 (7) | 0.0242 (6) | 0.0301 (7) | −0.0048 (5) | −0.0095 (5) | 0.0028 (5) |
C2 | 0.0346 (7) | 0.0310 (7) | 0.0271 (6) | −0.0078 (5) | −0.0085 (5) | 0.0046 (5) |
C3 | 0.0298 (6) | 0.0341 (7) | 0.0241 (6) | −0.0052 (5) | −0.0050 (5) | 0.0006 (5) |
C4 | 0.0286 (6) | 0.0270 (6) | 0.0240 (6) | −0.0032 (5) | −0.0048 (5) | −0.0003 (5) |
C5 | 0.0272 (6) | 0.0227 (6) | 0.0252 (6) | −0.0024 (5) | −0.0056 (5) | −0.0009 (5) |
C6 | 0.0299 (6) | 0.0271 (6) | 0.0225 (6) | −0.0023 (5) | 0.0001 (5) | −0.0034 (5) |
C7 | 0.0323 (6) | 0.0259 (6) | 0.0241 (6) | −0.0049 (5) | −0.0037 (5) | 0.0008 (5) |
C8 | 0.0373 (7) | 0.0215 (6) | 0.0311 (7) | −0.0002 (5) | −0.0023 (5) | −0.0018 (5) |
C9 | 0.0329 (7) | 0.0292 (6) | 0.0244 (6) | −0.0012 (5) | −0.0028 (5) | −0.0027 (5) |
C10 | 0.0409 (7) | 0.0279 (6) | 0.0252 (6) | −0.0075 (5) | −0.0032 (5) | 0.0005 (5) |
C11 | 0.0369 (7) | 0.0224 (6) | 0.0278 (6) | −0.0015 (5) | −0.0011 (5) | 0.0003 (5) |
C12 | 0.0443 (8) | 0.0249 (6) | 0.0306 (7) | −0.0076 (6) | −0.0030 (6) | 0.0001 (5) |
C13 | 0.0468 (8) | 0.0234 (6) | 0.0298 (7) | −0.0060 (6) | −0.0001 (6) | −0.0013 (5) |
C14 | 0.0772 (12) | 0.0299 (8) | 0.0452 (9) | −0.0202 (8) | 0.0012 (8) | −0.0020 (6) |
C15 | 0.0495 (9) | 0.0399 (8) | 0.0272 (7) | −0.0107 (7) | 0.0000 (6) | −0.0014 (6) |
C16 | 0.0397 (7) | 0.0263 (6) | 0.0318 (7) | −0.0006 (5) | 0.0011 (6) | −0.0050 (5) |
C17 | 0.0602 (10) | 0.0509 (9) | 0.0329 (8) | −0.0105 (8) | −0.0027 (7) | −0.0126 (7) |
C18 | 0.0856 (13) | 0.0344 (8) | 0.0513 (10) | −0.0160 (8) | 0.0122 (9) | −0.0163 (7) |
C19 | 0.0442 (8) | 0.0379 (8) | 0.0332 (7) | −0.0117 (6) | −0.0110 (6) | 0.0085 (6) |
O4 | 0.0427 (6) | 0.0327 (5) | 0.0423 (6) | 0.0030 (4) | 0.0069 (5) | 0.0031 (4) |
O5 | 0.0889 (10) | 0.0538 (8) | 0.0475 (7) | 0.0188 (7) | 0.0197 (7) | 0.0213 (6) |
O6 | 0.1316 (15) | 0.0443 (8) | 0.0737 (10) | 0.0239 (8) | 0.0071 (10) | −0.0100 (7) |
O7 | 0.1428 (16) | 0.0572 (9) | 0.0674 (10) | 0.0305 (9) | −0.0285 (10) | 0.0123 (7) |
N5 | 0.0492 (8) | 0.0353 (7) | 0.0557 (9) | 0.0007 (6) | 0.0019 (6) | 0.0043 (6) |
C20 | 0.0325 (7) | 0.0303 (7) | 0.0399 (8) | −0.0023 (5) | −0.0014 (6) | 0.0016 (6) |
C21 | 0.0546 (9) | 0.0396 (8) | 0.0343 (8) | 0.0008 (7) | 0.0020 (7) | −0.0066 (6) |
C22 | 0.0552 (9) | 0.0434 (8) | 0.0261 (7) | 0.0026 (7) | −0.0018 (6) | 0.0017 (6) |
C23 | 0.0307 (7) | 0.0337 (7) | 0.0315 (7) | −0.0016 (5) | 0.0001 (5) | 0.0017 (5) |
C24 | 0.0347 (7) | 0.0374 (7) | 0.0274 (7) | −0.0014 (6) | −0.0011 (5) | −0.0030 (5) |
C25 | 0.0352 (7) | 0.0390 (8) | 0.0308 (7) | −0.0037 (6) | −0.0045 (6) | 0.0042 (6) |
C26 | 0.0412 (8) | 0.0357 (8) | 0.0342 (7) | 0.0012 (6) | −0.0004 (6) | 0.0036 (6) |
O1W—O1W' | 1.196 (10) | C6—C7 | 1.3973 (18) |
O1W—H1W1 | 0.8112 | C7—C8 | 1.3865 (18) |
O1W—H2W1 | 0.8024 | C8—C9 | 1.3923 (18) |
O1W—H5W1 | 1.1709 | C10—C11 | 1.5170 (18) |
O1W'—H5W1 | 0.8189 | C10—H10A | 0.9800 |
O1W'—H6W1 | 0.8767 | C10—H10B | 0.9800 |
O1W'—H1W2 | 1.1808 | C11—C15 | 1.5182 (19) |
O2W—H6W1 | 1.2013 | C11—H11 | 0.9900 |
O2W—H1W2 | 0.8218 | C12—C14 | 1.5157 (19) |
O2W—H2W2 | 0.8195 | C12—C13 | 1.5223 (19) |
O2W'—H3W2 | 1.0717 | C12—H12 | 0.9900 |
O2W'—H4W2 | 0.8116 | C13—H13A | 0.9800 |
O1W"—H3W1 | 0.8237 | C13—H13B | 0.9800 |
O1W"—H4W1 | 0.8198 | C14—H14A | 0.9700 |
O2W"—H5W2 | 0.8223 | C14—H14B | 0.9700 |
O2W"—H6W2 | 0.8224 | C14—H14C | 0.9700 |
F1—C6 | 1.3573 (14) | C15—H15A | 0.9700 |
F2—C8 | 1.3508 (14) | C15—H15B | 0.9700 |
O1—C19 | 1.2124 (18) | C15—H15C | 0.9700 |
O2—C19 | 1.3224 (19) | C16—C18 | 1.490 (2) |
O2—H2O | 0.97 (3) | C16—C17 | 1.491 (2) |
O3—C3 | 1.2705 (16) | C16—H16 | 0.9900 |
N1—C1 | 1.3408 (16) | C17—C18 | 1.491 (2) |
N1—C5 | 1.4053 (16) | C17—H17A | 0.9800 |
N1—C16 | 1.4601 (16) | C17—H17B | 0.9800 |
N2—C9 | 1.3601 (17) | C18—H18A | 0.9800 |
N2—H2NA | 0.89 (2) | C18—H18B | 0.9800 |
N2—H2NB | 0.92 (2) | O4—C26 | 1.2682 (17) |
N3—C7 | 1.3986 (16) | O5—C26 | 1.2384 (18) |
N3—C13 | 1.4644 (16) | O6—N5 | 1.207 (2) |
N3—C10 | 1.4751 (17) | O7—N5 | 1.209 (2) |
N4—C11 | 1.4975 (16) | N5—C20 | 1.4694 (18) |
N4—C12 | 1.5053 (18) | C20—C25 | 1.374 (2) |
N4—H4NA | 0.960 (18) | C20—C21 | 1.380 (2) |
N4—H4NB | 0.913 (18) | C21—C22 | 1.380 (2) |
C1—C2 | 1.3633 (19) | C21—H21 | 0.9400 |
C1—H1 | 0.9400 | C22—C23 | 1.388 (2) |
C2—C3 | 1.4245 (19) | C22—H22 | 0.9400 |
C2—C19 | 1.4852 (18) | C23—C24 | 1.3916 (19) |
C3—C4 | 1.4506 (17) | C23—C26 | 1.5095 (19) |
C4—C9 | 1.4199 (18) | C24—C25 | 1.383 (2) |
C4—C5 | 1.4292 (17) | C24—H24 | 0.9400 |
C5—C6 | 1.3867 (17) | C25—H25 | 0.9400 |
O1W'—O1W—H1W1 | 104.5 | C10—C11—H11 | 108.7 |
O1W'—O1W—H2W1 | 133.2 | C15—C11—H11 | 108.7 |
H1W1—O1W—H2W1 | 110.0 | N4—C12—C14 | 109.29 (11) |
O1W'—O1W—H5W1 | 40.5 | N4—C12—C13 | 109.42 (11) |
H1W1—O1W—H5W1 | 64.5 | C14—C12—C13 | 111.47 (12) |
H2W1—O1W—H5W1 | 156.0 | N4—C12—H12 | 108.9 |
O1W—O1W'—H5W1 | 68.1 | C14—C12—H12 | 108.9 |
O1W—O1W'—H6W1 | 102.1 | C13—C12—H12 | 108.9 |
H5W1—O1W'—H6W1 | 150.1 | N3—C13—C12 | 110.13 (11) |
O1W—O1W'—H1W2 | 126.7 | N3—C13—H13A | 109.6 |
H5W1—O1W'—H1W2 | 146.3 | C12—C13—H13A | 109.6 |
H6W1—O1W'—H1W2 | 25.0 | N3—C13—H13B | 109.6 |
H6W1—O2W—H1W2 | 21.9 | C12—C13—H13B | 109.6 |
H6W1—O2W—H2W2 | 104.5 | H13A—C13—H13B | 108.1 |
H1W2—O2W—H2W2 | 106.0 | C12—C14—H14A | 109.5 |
H3W2—O2W'—H4W2 | 122.7 | C12—C14—H14B | 109.5 |
H3W1—O1W"—H4W1 | 104.8 | H14A—C14—H14B | 109.5 |
H5W2—O2W"—H6W2 | 104.4 | C12—C14—H14C | 109.5 |
C19—O2—H2O | 105.3 (14) | H14A—C14—H14C | 109.5 |
C1—N1—C5 | 119.87 (11) | H14B—C14—H14C | 109.5 |
C1—N1—C16 | 118.82 (11) | C11—C15—H15A | 109.5 |
C5—N1—C16 | 121.29 (10) | C11—C15—H15B | 109.5 |
C9—N2—H2NA | 120.4 (14) | H15A—C15—H15B | 109.5 |
C9—N2—H2NB | 115.8 (12) | C11—C15—H15C | 109.5 |
H2NA—N2—H2NB | 123.3 (18) | H15A—C15—H15C | 109.5 |
C7—N3—C13 | 120.17 (11) | H15B—C15—H15C | 109.5 |
C7—N3—C10 | 116.79 (11) | N1—C16—C18 | 119.56 (13) |
C13—N3—C10 | 111.65 (10) | N1—C16—C17 | 118.95 (12) |
C11—N4—C12 | 111.82 (10) | C18—C16—C17 | 60.01 (11) |
C11—N4—H4NA | 111.3 (10) | N1—C16—H16 | 115.6 |
C12—N4—H4NA | 109.6 (11) | C18—C16—H16 | 115.6 |
C11—N4—H4NB | 110.7 (11) | C17—C16—H16 | 115.6 |
C12—N4—H4NB | 109.2 (11) | C18—C17—C16 | 59.96 (11) |
H4NA—N4—H4NB | 104.0 (14) | C18—C17—H17A | 117.8 |
N1—C1—C2 | 124.37 (12) | C16—C17—H17A | 117.8 |
N1—C1—H1 | 117.8 | C18—C17—H17B | 117.8 |
C2—C1—H1 | 117.8 | C16—C17—H17B | 117.8 |
C1—C2—C3 | 120.03 (12) | H17A—C17—H17B | 114.9 |
C1—C2—C19 | 118.03 (12) | C16—C18—C17 | 60.03 (10) |
C3—C2—C19 | 121.93 (12) | C16—C18—H18A | 117.8 |
O3—C3—C2 | 120.95 (12) | C17—C18—H18A | 117.8 |
O3—C3—C4 | 122.34 (12) | C16—C18—H18B | 117.8 |
C2—C3—C4 | 116.71 (11) | C17—C18—H18B | 117.8 |
C9—C4—C5 | 118.93 (11) | H18A—C18—H18B | 114.9 |
C9—C4—C3 | 120.79 (11) | O1—C19—O2 | 120.84 (13) |
C5—C4—C3 | 120.28 (11) | O1—C19—C2 | 122.93 (14) |
C6—C5—N1 | 122.45 (11) | O2—C19—C2 | 116.23 (13) |
C6—C5—C4 | 118.84 (11) | O6—N5—O7 | 122.86 (15) |
N1—C5—C4 | 118.70 (11) | O6—N5—C20 | 118.87 (15) |
F1—C6—C5 | 120.87 (11) | O7—N5—C20 | 118.25 (14) |
F1—C6—C7 | 115.55 (11) | C25—C20—C21 | 122.68 (13) |
C5—C6—C7 | 123.46 (11) | C25—C20—N5 | 118.74 (13) |
C8—C7—C6 | 115.87 (11) | C21—C20—N5 | 118.56 (13) |
C8—C7—N3 | 125.60 (12) | C22—C21—C20 | 118.18 (14) |
C6—C7—N3 | 118.49 (11) | C22—C21—H21 | 120.9 |
F2—C8—C7 | 119.99 (11) | C20—C21—H21 | 120.9 |
F2—C8—C9 | 115.54 (11) | C21—C22—C23 | 120.96 (14) |
C7—C8—C9 | 124.44 (12) | C21—C22—H22 | 119.5 |
N2—C9—C8 | 118.91 (12) | C23—C22—H22 | 119.5 |
N2—C9—C4 | 122.81 (12) | C22—C23—C24 | 119.14 (13) |
C8—C9—C4 | 118.21 (11) | C22—C23—C26 | 119.83 (13) |
N3—C10—C11 | 109.88 (11) | C24—C23—C26 | 120.96 (13) |
N3—C10—H10A | 109.7 | C25—C24—C23 | 120.74 (13) |
C11—C10—H10A | 109.7 | C25—C24—H24 | 119.6 |
N3—C10—H10B | 109.7 | C23—C24—H24 | 119.6 |
C11—C10—H10B | 109.7 | C20—C25—C24 | 118.29 (13) |
H10A—C10—H10B | 108.2 | C20—C25—H25 | 120.9 |
N4—C11—C10 | 107.6 (1) | C24—C25—H25 | 120.9 |
N4—C11—C15 | 109.68 (11) | O5—C26—O4 | 124.62 (14) |
C10—C11—C15 | 113.43 (12) | O5—C26—C23 | 118.92 (13) |
N4—C11—H11 | 108.7 | O4—C26—C23 | 116.44 (12) |
C5—N1—C1—C2 | 1.5 (2) | C5—C4—C9—C8 | 1.62 (18) |
C16—N1—C1—C2 | −176.94 (13) | C3—C4—C9—C8 | −179.06 (12) |
N1—C1—C2—C3 | −0.6 (2) | C7—N3—C10—C11 | −155.08 (11) |
N1—C1—C2—C19 | 178.70 (12) | C13—N3—C10—C11 | 61.19 (14) |
C1—C2—C3—O3 | −179.23 (13) | C12—N4—C11—C10 | 58.92 (14) |
C19—C2—C3—O3 | 1.5 (2) | C12—N4—C11—C15 | −177.27 (11) |
C1—C2—C3—C4 | 0.35 (18) | N3—C10—C11—N4 | −59.62 (14) |
C19—C2—C3—C4 | −178.93 (12) | N3—C10—C11—C15 | 178.88 (11) |
O3—C3—C4—C9 | −0.8 (2) | C11—N4—C12—C14 | −179.49 (12) |
C2—C3—C4—C9 | 179.66 (12) | C11—N4—C12—C13 | −57.18 (14) |
O3—C3—C4—C5 | 178.54 (12) | C7—N3—C13—C12 | 159.20 (12) |
C2—C3—C4—C5 | −1.03 (18) | C10—N3—C13—C12 | −58.45 (15) |
C1—N1—C5—C6 | 176.48 (12) | N4—C12—C13—N3 | 55.29 (15) |
C16—N1—C5—C6 | −5.09 (19) | C14—C12—C13—N3 | 176.29 (13) |
C1—N1—C5—C4 | −2.13 (17) | C1—N1—C16—C18 | 36.0 (2) |
C16—N1—C5—C4 | 176.30 (12) | C5—N1—C16—C18 | −142.40 (14) |
C9—C4—C5—C6 | 2.57 (18) | C1—N1—C16—C17 | 105.99 (15) |
C3—C4—C5—C6 | −176.75 (12) | C5—N1—C16—C17 | −72.46 (17) |
C9—C4—C5—N1 | −178.76 (11) | N1—C16—C17—C18 | −109.38 (15) |
C3—C4—C5—N1 | 1.92 (18) | N1—C16—C18—C17 | 108.37 (15) |
N1—C5—C6—F1 | −8.58 (19) | C1—C2—C19—O1 | −4.0 (2) |
C4—C5—C6—F1 | 170.03 (11) | C3—C2—C19—O1 | 175.27 (14) |
N1—C5—C6—C7 | 175.64 (12) | C1—C2—C19—O2 | 176.23 (13) |
C4—C5—C6—C7 | −5.75 (19) | C3—C2—C19—O2 | −4.5 (2) |
F1—C6—C7—C8 | −171.68 (11) | O6—N5—C20—C25 | 175.16 (17) |
C5—C6—C7—C8 | 4.30 (19) | O7—N5—C20—C25 | −3.3 (2) |
F1—C6—C7—N3 | 5.98 (18) | O6—N5—C20—C21 | −6.6 (2) |
C5—C6—C7—N3 | −178.03 (12) | O7—N5—C20—C21 | 174.94 (18) |
C13—N3—C7—C8 | 18.0 (2) | C25—C20—C21—C22 | 0.6 (2) |
C10—N3—C7—C8 | −122.47 (14) | N5—C20—C21—C22 | −177.55 (15) |
C13—N3—C7—C6 | −159.38 (12) | C20—C21—C22—C23 | −1.2 (3) |
C10—N3—C7—C6 | 60.12 (16) | C21—C22—C23—C24 | 1.2 (2) |
C6—C7—C8—F2 | −177.64 (12) | C21—C22—C23—C26 | −175.88 (15) |
N3—C7—C8—F2 | 4.9 (2) | C22—C23—C24—C25 | −0.7 (2) |
C6—C7—C8—C9 | 0.3 (2) | C26—C23—C24—C25 | 176.36 (13) |
N3—C7—C8—C9 | −177.18 (13) | C21—C20—C25—C24 | −0.1 (2) |
F2—C8—C9—N2 | −2.18 (19) | N5—C20—C25—C24 | 178.04 (13) |
C7—C8—C9—N2 | 179.79 (13) | C23—C24—C25—C20 | 0.2 (2) |
F2—C8—C9—C4 | 174.87 (11) | C22—C23—C26—O5 | −31.0 (2) |
C7—C8—C9—C4 | −3.2 (2) | C24—C23—C26—O5 | 151.92 (17) |
C5—C4—C9—N2 | 178.55 (13) | C22—C23—C26—O4 | 147.01 (15) |
C3—C4—C9—N2 | −2.1 (2) | C24—C23—C26—O4 | −30.0 (2) |
D—H···A | D—H | H···A | D···A | D—H···A |
O2—H2O···O3 | 0.97 (3) | 1.60 (3) | 2.5257 (15) | 157 (2) |
N2—H2NB···O3 | 0.92 (2) | 1.901 (19) | 2.6343 (17) | 135.0 (16) |
N4—H4NA···O4 | 0.960 (18) | 1.824 (18) | 2.7666 (15) | 166.4 (15) |
O1W—H1W1···O5 | 0.81 | 2.00 | 2.806 (2) | 173 |
O2W—H1W2···O1W | 0.82 | 2.12 | 2.811 (5) | 141 |
O1W—H2W1···O2Wi | 0.80 | 2.01 | 2.803 (5) | 172 |
O2W—H2W2···O1ii | 0.82 | 2.02 | 2.807 (3) | 161 |
N2—H2NA···O1Wiii | 0.89 (2) | 2.07 (2) | 2.947 (2) | 167.8 (19) |
N4—H4NB···O4iv | 0.913 (18) | 1.957 (18) | 2.8405 (16) | 162.5 (15) |
Symmetry codes: (i) −x+2, −y+1, −z; (ii) −x+1, −y, −z+1; (iii) x−1, y, z+1; (iv) −x+1, −y+1, −z+1. |
C19H23F2N4O3+·C8H7O2− | Z = 2 |
Mr = 528.55 | F(000) = 556 |
Triclinic, P1 | Dx = 1.428 Mg m−3 |
a = 10.0222 (4) Å | Mo Kα radiation, λ = 0.71073 Å |
b = 10.1145 (4) Å | Cell parameters from 9186 reflections |
c = 13.5255 (5) Å | θ = 3.0–27.5° |
α = 69.606 (2)° | µ = 0.11 mm−1 |
β = 73.032 (2)° | T = 90 K |
γ = 83.747 (2)° | Irregular block, pale yellow |
V = 1229.15 (9) Å3 | 0.34 × 0.28 × 0.26 mm |
Bruker D8 Venture dual source diffractometer | 5639 independent reflections |
Radiation source: microsource | 5029 reflections with I > 2σ(I) |
Detector resolution: 7.41 pixels mm-1 | Rint = 0.038 |
φ and ω scans | θmax = 27.5°, θmin = 2.1° |
Absorption correction: multi-scan (SADABS; Krause et al., 2015) | h = −12→12 |
Tmin = 0.914, Tmax = 0.959 | k = −12→13 |
41293 measured reflections | l = −17→17 |
Refinement on F2 | Primary atom site location: structure-invariant direct methods |
Least-squares matrix: full | Secondary atom site location: difference Fourier map |
R[F2 > 2σ(F2)] = 0.034 | Hydrogen site location: mixed |
wR(F2) = 0.092 | H atoms treated by a mixture of independent and constrained refinement |
S = 1.02 | w = 1/[σ2(Fo2) + (0.0413P)2 + 0.5792P] where P = (Fo2 + 2Fc2)/3 |
5639 reflections | (Δ/σ)max = 0.002 |
365 parameters | Δρmax = 0.37 e Å−3 |
0 restraints | Δρmin = −0.20 e Å−3 |
Experimental. The crystal was mounted using polyisobutene oil on the tip of a fine glass fibre, which was fastened in a copper mounting pin with electrical solder. It was placed directly into the cold gas stream of a liquid-nitrogen based cryostat (Hope, 1994; Parkin & Hope, 1998). Diffraction data were collected with the crystal at 90K, which is standard practice in this laboratory for the majority of flash-cooled crystals. |
Geometry. All esds (except the esd in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell esds are taken into account individually in the estimation of esds in distances, angles and torsion angles; correlations between esds in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell esds is used for estimating esds involving l.s. planes. |
Refinement. Refinement progress was checked using Platon (Spek, 2020) and by an R-tensor (Parkin, 2000). The final model was further checked with the IUCr utility checkCIF. |
x | y | z | Uiso*/Ueq | ||
F1 | 0.70792 (7) | 0.00637 (7) | 0.83721 (5) | 0.01777 (15) | |
F2 | 0.63127 (7) | 0.35650 (7) | 1.00282 (5) | 0.01665 (14) | |
O1 | 1.05409 (8) | −0.41085 (8) | 1.22035 (7) | 0.01857 (17) | |
O2 | 1.00723 (10) | −0.25755 (9) | 1.31012 (7) | 0.02240 (19) | |
H2O | 0.970 (2) | −0.164 (2) | 1.2943 (16) | 0.051 (5)* | |
O3 | 0.89918 (9) | −0.02316 (8) | 1.22819 (6) | 0.01721 (17) | |
N1 | 0.84402 (9) | −0.17056 (9) | 0.99535 (7) | 0.01228 (18) | |
N2 | 0.77272 (12) | 0.21351 (11) | 1.14682 (8) | 0.0201 (2) | |
H2NA | 0.7380 (17) | 0.2964 (18) | 1.1458 (13) | 0.029 (4)* | |
H2NB | 0.8144 (17) | 0.1606 (17) | 1.1985 (13) | 0.027 (4)* | |
N3 | 0.59393 (10) | 0.26309 (10) | 0.84423 (7) | 0.01448 (19) | |
N4 | 0.58386 (10) | 0.38019 (10) | 0.62261 (7) | 0.01321 (18) | |
H4NA | 0.6191 (17) | 0.3897 (17) | 0.5467 (13) | 0.029 (4)* | |
H4NB | 0.5030 (16) | 0.4386 (16) | 0.6268 (12) | 0.023 (4)* | |
C1 | 0.91214 (11) | −0.24536 (11) | 1.06947 (9) | 0.0133 (2) | |
H1 | 0.950209 | −0.334367 | 1.065994 | 0.016* | |
C2 | 0.93024 (11) | −0.20187 (11) | 1.14943 (8) | 0.0134 (2) | |
C3 | 0.88013 (11) | −0.06613 (11) | 1.15534 (8) | 0.0129 (2) | |
C4 | 0.80895 (11) | 0.01794 (11) | 1.07502 (8) | 0.0123 (2) | |
C5 | 0.78917 (11) | −0.03613 (11) | 0.99549 (8) | 0.0119 (2) | |
C6 | 0.71912 (11) | 0.04728 (11) | 0.91986 (8) | 0.0131 (2) | |
C7 | 0.66418 (11) | 0.18133 (11) | 0.91898 (8) | 0.0128 (2) | |
C8 | 0.68554 (11) | 0.22948 (11) | 0.99773 (9) | 0.0135 (2) | |
C9 | 0.75685 (11) | 0.15531 (11) | 1.07451 (8) | 0.0131 (2) | |
C10 | 0.49686 (11) | 0.20780 (11) | 0.80689 (8) | 0.0137 (2) | |
H10A | 0.405327 | 0.255422 | 0.822658 | 0.016* | |
H10B | 0.483568 | 0.105862 | 0.848679 | 0.016* | |
C11 | 0.54638 (11) | 0.22823 (11) | 0.68460 (8) | 0.0132 (2) | |
H11 | 0.630826 | 0.167958 | 0.670230 | 0.016* | |
C12 | 0.68765 (11) | 0.43180 (11) | 0.66142 (9) | 0.0149 (2) | |
H12 | 0.775319 | 0.374507 | 0.651603 | 0.018* | |
C13 | 0.62643 (12) | 0.41177 (11) | 0.78307 (9) | 0.0145 (2) | |
H13A | 0.694316 | 0.443183 | 0.810613 | 0.017* | |
H13B | 0.540560 | 0.469619 | 0.793619 | 0.017* | |
C14 | 0.72062 (14) | 0.58531 (13) | 0.59395 (10) | 0.0242 (3) | |
H14A | 0.755513 | 0.594990 | 0.516135 | 0.036* | |
H14B | 0.791838 | 0.617518 | 0.616781 | 0.036* | |
H14C | 0.635807 | 0.642584 | 0.605345 | 0.036* | |
C15 | 0.43375 (12) | 0.18919 (12) | 0.64521 (9) | 0.0176 (2) | |
H15A | 0.466770 | 0.208543 | 0.565850 | 0.026* | |
H15B | 0.349399 | 0.245187 | 0.662023 | 0.026* | |
H15C | 0.412447 | 0.088674 | 0.682358 | 0.026* | |
C16 | 0.83214 (11) | −0.23184 (11) | 0.91487 (8) | 0.0139 (2) | |
H16 | 0.885555 | −0.182759 | 0.837347 | 0.017* | |
C17 | 0.69701 (12) | −0.29534 (12) | 0.92921 (9) | 0.0190 (2) | |
H17A | 0.668119 | −0.282994 | 0.862478 | 0.023* | |
H17B | 0.619520 | −0.295690 | 0.994438 | 0.023* | |
C18 | 0.82133 (13) | −0.38861 (12) | 0.94729 (9) | 0.0189 (2) | |
H18A | 0.820179 | −0.446110 | 1.023612 | 0.023* | |
H18B | 0.868786 | −0.433412 | 0.891632 | 0.023* | |
C19 | 1.00275 (11) | −0.29946 (12) | 1.22819 (9) | 0.0153 (2) | |
O4 | 0.35788 (9) | 0.55031 (9) | 0.60167 (6) | 0.01934 (18) | |
O5 | 0.29414 (9) | 0.53584 (9) | 0.77723 (7) | 0.02231 (19) | |
C20 | 0.18020 (11) | 0.80365 (11) | 0.56629 (9) | 0.0143 (2) | |
C21 | 0.27729 (12) | 0.89939 (12) | 0.55673 (9) | 0.0183 (2) | |
H21 | 0.327649 | 0.877691 | 0.610123 | 0.022* | |
C22 | 0.30119 (13) | 1.02595 (13) | 0.47016 (10) | 0.0221 (2) | |
H22 | 0.367933 | 1.090038 | 0.464389 | 0.026* | |
C23 | 0.22759 (13) | 1.05909 (12) | 0.39183 (9) | 0.0213 (2) | |
H23 | 0.243173 | 1.146127 | 0.332936 | 0.026* | |
C24 | 0.13151 (12) | 0.96463 (12) | 0.40009 (9) | 0.0194 (2) | |
H24 | 0.081044 | 0.986744 | 0.346737 | 0.023* | |
C25 | 0.10881 (12) | 0.83743 (12) | 0.48642 (9) | 0.0164 (2) | |
H25 | 0.043610 | 0.772607 | 0.490962 | 0.020* | |
C26 | 0.14869 (11) | 0.66952 (12) | 0.66354 (9) | 0.0157 (2) | |
H26A | 0.083521 | 0.612589 | 0.652443 | 0.019* | |
H26B | 0.100571 | 0.694457 | 0.729885 | 0.019* | |
C27 | 0.27658 (11) | 0.57882 (11) | 0.68409 (9) | 0.0142 (2) |
U11 | U22 | U33 | U12 | U13 | U23 | |
F1 | 0.0263 (4) | 0.0183 (3) | 0.0142 (3) | 0.0045 (3) | −0.0104 (3) | −0.0093 (3) |
F2 | 0.0211 (3) | 0.0131 (3) | 0.0188 (3) | 0.0042 (2) | −0.0083 (3) | −0.0079 (3) |
O1 | 0.0188 (4) | 0.0148 (4) | 0.0223 (4) | 0.0014 (3) | −0.0083 (3) | −0.0047 (3) |
O2 | 0.0312 (5) | 0.0204 (4) | 0.0215 (4) | 0.0064 (4) | −0.0166 (4) | −0.0083 (3) |
O3 | 0.0221 (4) | 0.0179 (4) | 0.0160 (4) | 0.0021 (3) | −0.0099 (3) | −0.0077 (3) |
N1 | 0.0138 (4) | 0.0119 (4) | 0.0115 (4) | −0.0007 (3) | −0.0029 (3) | −0.0045 (3) |
N2 | 0.0308 (6) | 0.0160 (5) | 0.0210 (5) | 0.0070 (4) | −0.0152 (4) | −0.0106 (4) |
N3 | 0.0179 (5) | 0.0123 (4) | 0.0139 (4) | −0.0017 (3) | −0.0078 (4) | −0.0020 (3) |
N4 | 0.0144 (4) | 0.0134 (4) | 0.0109 (4) | 0.0004 (3) | −0.0036 (3) | −0.0031 (3) |
C1 | 0.0114 (5) | 0.0126 (5) | 0.0139 (5) | −0.0008 (4) | −0.0016 (4) | −0.0032 (4) |
C2 | 0.0127 (5) | 0.0135 (5) | 0.0127 (5) | −0.0013 (4) | −0.0031 (4) | −0.0027 (4) |
C3 | 0.0116 (5) | 0.0147 (5) | 0.0117 (5) | −0.0026 (4) | −0.0016 (4) | −0.0038 (4) |
C4 | 0.0123 (5) | 0.0134 (5) | 0.0107 (5) | −0.0015 (4) | −0.0023 (4) | −0.0038 (4) |
C5 | 0.0120 (5) | 0.0115 (5) | 0.0109 (5) | −0.0014 (4) | −0.0011 (4) | −0.0036 (4) |
C6 | 0.0151 (5) | 0.0157 (5) | 0.0100 (5) | −0.0015 (4) | −0.0031 (4) | −0.0059 (4) |
C7 | 0.0117 (5) | 0.0141 (5) | 0.0108 (5) | −0.0018 (4) | −0.0020 (4) | −0.0025 (4) |
C8 | 0.0146 (5) | 0.0112 (5) | 0.0142 (5) | 0.0008 (4) | −0.0026 (4) | −0.0048 (4) |
C9 | 0.0140 (5) | 0.0141 (5) | 0.0113 (5) | −0.0013 (4) | −0.0026 (4) | −0.0047 (4) |
C10 | 0.0132 (5) | 0.0157 (5) | 0.0125 (5) | −0.0012 (4) | −0.0038 (4) | −0.0042 (4) |
C11 | 0.0142 (5) | 0.0124 (5) | 0.0126 (5) | 0.0002 (4) | −0.0035 (4) | −0.0040 (4) |
C12 | 0.0147 (5) | 0.0151 (5) | 0.0145 (5) | −0.0014 (4) | −0.0056 (4) | −0.0028 (4) |
C13 | 0.0173 (5) | 0.0120 (5) | 0.0145 (5) | 0.0002 (4) | −0.0063 (4) | −0.0033 (4) |
C14 | 0.0316 (7) | 0.0180 (6) | 0.0206 (6) | −0.0087 (5) | −0.0097 (5) | 0.0011 (5) |
C15 | 0.0189 (5) | 0.0206 (6) | 0.0152 (5) | −0.0025 (4) | −0.0057 (4) | −0.0068 (4) |
C16 | 0.0179 (5) | 0.0135 (5) | 0.0114 (5) | −0.0007 (4) | −0.0032 (4) | −0.0058 (4) |
C17 | 0.0203 (6) | 0.0218 (6) | 0.0178 (5) | −0.0047 (4) | −0.0043 (4) | −0.0093 (4) |
C18 | 0.0276 (6) | 0.0138 (5) | 0.0169 (5) | −0.0023 (4) | −0.0063 (4) | −0.0062 (4) |
C19 | 0.0133 (5) | 0.0157 (5) | 0.0156 (5) | −0.0021 (4) | −0.0047 (4) | −0.0026 (4) |
O4 | 0.0206 (4) | 0.0220 (4) | 0.0134 (4) | 0.0070 (3) | −0.0039 (3) | −0.0063 (3) |
O5 | 0.0283 (5) | 0.0249 (4) | 0.0148 (4) | 0.0089 (4) | −0.0089 (3) | −0.0082 (3) |
C20 | 0.0147 (5) | 0.0138 (5) | 0.0140 (5) | 0.0033 (4) | −0.0021 (4) | −0.0065 (4) |
C21 | 0.0213 (6) | 0.0183 (5) | 0.0170 (5) | −0.0004 (4) | −0.0063 (4) | −0.0070 (4) |
C22 | 0.0279 (6) | 0.0171 (5) | 0.0217 (6) | −0.0041 (5) | −0.0044 (5) | −0.0078 (5) |
C23 | 0.0303 (6) | 0.0140 (5) | 0.0159 (5) | 0.0031 (5) | −0.0031 (5) | −0.0038 (4) |
C24 | 0.0217 (6) | 0.0215 (6) | 0.0149 (5) | 0.0076 (4) | −0.0064 (4) | −0.0071 (4) |
C25 | 0.0149 (5) | 0.0186 (5) | 0.0166 (5) | 0.0023 (4) | −0.0033 (4) | −0.0085 (4) |
C26 | 0.0144 (5) | 0.0163 (5) | 0.0147 (5) | 0.0009 (4) | −0.0030 (4) | −0.0041 (4) |
C27 | 0.0158 (5) | 0.0117 (5) | 0.0144 (5) | −0.0006 (4) | −0.0033 (4) | −0.0041 (4) |
F1—C6 | 1.3562 (11) | C12—C13 | 1.5266 (15) |
F2—C8 | 1.3560 (12) | C12—H12 | 1.0000 |
O1—C19 | 1.2126 (14) | C13—H13A | 0.9900 |
O2—C19 | 1.3304 (14) | C13—H13B | 0.9900 |
O2—H2O | 0.95 (2) | C14—H14A | 0.9800 |
O3—C3 | 1.2738 (13) | C14—H14B | 0.9800 |
N1—C1 | 1.3423 (14) | C14—H14C | 0.9800 |
N1—C5 | 1.4104 (13) | C15—H15A | 0.9800 |
N1—C16 | 1.4646 (13) | C15—H15B | 0.9800 |
N2—C9 | 1.3567 (14) | C15—H15C | 0.9800 |
N2—H2NA | 0.869 (17) | C16—C17 | 1.4945 (15) |
N2—H2NB | 0.900 (17) | C16—C18 | 1.4978 (15) |
N3—C7 | 1.3812 (14) | C16—H16 | 1.0000 |
N3—C10 | 1.4548 (13) | C17—C18 | 1.5044 (17) |
N3—C13 | 1.4609 (13) | C17—H17A | 0.9900 |
N4—C11 | 1.5000 (13) | C17—H17B | 0.9900 |
N4—C12 | 1.5026 (13) | C18—H18A | 0.9900 |
N4—H4NA | 0.956 (16) | C18—H18B | 0.9900 |
N4—H4NB | 0.949 (16) | O4—C27 | 1.2777 (13) |
C1—C2 | 1.3636 (15) | O5—C27 | 1.2401 (13) |
C1—H1 | 0.9500 | C20—C25 | 1.3916 (15) |
C2—C3 | 1.4305 (15) | C20—C21 | 1.3949 (16) |
C2—C19 | 1.4833 (15) | C20—C26 | 1.5091 (15) |
C3—C4 | 1.4452 (14) | C21—C22 | 1.3876 (17) |
C4—C9 | 1.4285 (15) | C21—H21 | 0.9500 |
C4—C5 | 1.4329 (14) | C22—C23 | 1.3906 (18) |
C5—C6 | 1.3927 (15) | C22—H22 | 0.9500 |
C6—C7 | 1.4041 (15) | C23—C24 | 1.3841 (18) |
C7—C8 | 1.3910 (14) | C23—H23 | 0.9500 |
C8—C9 | 1.3877 (15) | C24—C25 | 1.3900 (16) |
C10—C11 | 1.5264 (14) | C24—H24 | 0.9500 |
C10—H10A | 0.9900 | C25—H25 | 0.9500 |
C10—H10B | 0.9900 | C26—C27 | 1.5283 (15) |
C11—C15 | 1.5194 (15) | C26—H26A | 0.9900 |
C11—H11 | 1.0000 | C26—H26B | 0.9900 |
C12—C14 | 1.5169 (15) | ||
C19—O2—H2O | 105.6 (12) | N3—C13—H13B | 109.8 |
C1—N1—C5 | 119.83 (9) | C12—C13—H13B | 109.8 |
C1—N1—C16 | 117.94 (9) | H13A—C13—H13B | 108.2 |
C5—N1—C16 | 122.22 (9) | C12—C14—H14A | 109.5 |
C9—N2—H2NA | 120.6 (11) | C12—C14—H14B | 109.5 |
C9—N2—H2NB | 117.6 (10) | H14A—C14—H14B | 109.5 |
H2NA—N2—H2NB | 121.7 (14) | C12—C14—H14C | 109.5 |
C7—N3—C10 | 124.24 (9) | H14A—C14—H14C | 109.5 |
C7—N3—C13 | 122.03 (9) | H14B—C14—H14C | 109.5 |
C10—N3—C13 | 113.16 (8) | C11—C15—H15A | 109.5 |
C11—N4—C12 | 112.99 (8) | C11—C15—H15B | 109.5 |
C11—N4—H4NA | 107.3 (10) | H15A—C15—H15B | 109.5 |
C12—N4—H4NA | 111.1 (10) | C11—C15—H15C | 109.5 |
C11—N4—H4NB | 110.9 (9) | H15A—C15—H15C | 109.5 |
C12—N4—H4NB | 109.4 (9) | H15B—C15—H15C | 109.5 |
H4NA—N4—H4NB | 104.9 (13) | N1—C16—C17 | 119.36 (9) |
N1—C1—C2 | 124.25 (10) | N1—C16—C18 | 119.26 (9) |
N1—C1—H1 | 117.9 | C17—C16—C18 | 60.36 (8) |
C2—C1—H1 | 117.9 | N1—C16—H16 | 115.6 |
C1—C2—C3 | 120.08 (10) | C17—C16—H16 | 115.6 |
C1—C2—C19 | 117.76 (10) | C18—C16—H16 | 115.6 |
C3—C2—C19 | 122.16 (10) | C16—C17—C18 | 59.93 (7) |
O3—C3—C2 | 120.62 (10) | C16—C17—H17A | 117.8 |
O3—C3—C4 | 122.58 (10) | C18—C17—H17A | 117.8 |
C2—C3—C4 | 116.80 (9) | C16—C17—H17B | 117.8 |
C9—C4—C5 | 119.35 (9) | C18—C17—H17B | 117.8 |
C9—C4—C3 | 120.38 (9) | H17A—C17—H17B | 114.9 |
C5—C4—C3 | 120.28 (9) | C16—C18—C17 | 59.71 (7) |
C6—C5—N1 | 122.53 (9) | C16—C18—H18A | 117.8 |
C6—C5—C4 | 118.75 (9) | C17—C18—H18A | 117.8 |
N1—C5—C4 | 118.71 (9) | C16—C18—H18B | 117.8 |
F1—C6—C5 | 121.11 (9) | C17—C18—H18B | 117.8 |
F1—C6—C7 | 115.64 (9) | H18A—C18—H18B | 114.9 |
C5—C6—C7 | 123.12 (9) | O1—C19—O2 | 121.36 (10) |
N3—C7—C8 | 121.0 (1) | O1—C19—C2 | 123.17 (10) |
N3—C7—C6 | 122.83 (9) | O2—C19—C2 | 115.47 (10) |
C8—C7—C6 | 116.17 (9) | C25—C20—C21 | 118.45 (10) |
F2—C8—C9 | 116.52 (9) | C25—C20—C26 | 120.7 (1) |
F2—C8—C7 | 118.76 (9) | C21—C20—C26 | 120.8 (1) |
C9—C8—C7 | 124.71 (10) | C22—C21—C20 | 120.78 (11) |
N2—C9—C8 | 119.61 (10) | C22—C21—H21 | 119.6 |
N2—C9—C4 | 122.51 (10) | C20—C21—H21 | 119.6 |
C8—C9—C4 | 117.87 (9) | C21—C22—C23 | 120.09 (11) |
N3—C10—C11 | 112.99 (9) | C21—C22—H22 | 120.0 |
N3—C10—H10A | 109.0 | C23—C22—H22 | 120.0 |
C11—C10—H10A | 109.0 | C24—C23—C22 | 119.67 (11) |
N3—C10—H10B | 109.0 | C24—C23—H23 | 120.2 |
C11—C10—H10B | 109.0 | C22—C23—H23 | 120.2 |
H10A—C10—H10B | 107.8 | C23—C24—C25 | 120.03 (11) |
N4—C11—C15 | 108.99 (9) | C23—C24—H24 | 120.0 |
N4—C11—C10 | 108.68 (8) | C25—C24—H24 | 120.0 |
C15—C11—C10 | 111.49 (9) | C24—C25—C20 | 120.96 (11) |
N4—C11—H11 | 109.2 | C24—C25—H25 | 119.5 |
C15—C11—H11 | 109.2 | C20—C25—H25 | 119.5 |
C10—C11—H11 | 109.2 | C20—C26—C27 | 114.65 (9) |
N4—C12—C14 | 109.52 (9) | C20—C26—H26A | 108.6 |
N4—C12—C13 | 108.54 (9) | C27—C26—H26A | 108.6 |
C14—C12—C13 | 111.62 (9) | C20—C26—H26B | 108.6 |
N4—C12—H12 | 109.0 | C27—C26—H26B | 108.6 |
C14—C12—H12 | 109.0 | H26A—C26—H26B | 107.6 |
C13—C12—H12 | 109.0 | O5—C27—O4 | 124.4 (1) |
N3—C13—C12 | 109.59 (9) | O5—C27—C26 | 119.62 (10) |
N3—C13—H13A | 109.8 | O4—C27—C26 | 115.97 (9) |
C12—C13—H13A | 109.8 | ||
C5—N1—C1—C2 | 1.77 (16) | C7—C8—C9—C4 | −1.82 (16) |
C16—N1—C1—C2 | −179.51 (10) | C5—C4—C9—N2 | −179.51 (10) |
N1—C1—C2—C3 | −2.65 (17) | C3—C4—C9—N2 | 0.89 (16) |
N1—C1—C2—C19 | 177.40 (9) | C5—C4—C9—C8 | 1.59 (15) |
C1—C2—C3—O3 | −178.44 (10) | C3—C4—C9—C8 | −178.01 (9) |
C19—C2—C3—O3 | 1.50 (16) | C7—N3—C10—C11 | −116.00 (11) |
C1—C2—C3—C4 | 1.16 (15) | C13—N3—C10—C11 | 55.53 (12) |
C19—C2—C3—C4 | −178.89 (9) | C12—N4—C11—C15 | 175.95 (9) |
O3—C3—C4—C9 | 0.20 (16) | C12—N4—C11—C10 | 54.26 (11) |
C2—C3—C4—C9 | −179.39 (9) | N3—C10—C11—N4 | −51.50 (11) |
O3—C3—C4—C5 | −179.40 (9) | N3—C10—C11—C15 | −171.65 (9) |
C2—C3—C4—C5 | 1.01 (15) | C11—N4—C12—C14 | 179.47 (9) |
C1—N1—C5—C6 | 179.14 (10) | C11—N4—C12—C13 | −58.45 (11) |
C16—N1—C5—C6 | 0.48 (15) | C7—N3—C13—C12 | 113.64 (11) |
C1—N1—C5—C4 | 0.54 (14) | C10—N3—C13—C12 | −58.10 (12) |
C16—N1—C5—C4 | −178.13 (9) | N4—C12—C13—N3 | 58.10 (11) |
C9—C4—C5—C6 | −0.12 (15) | C14—C12—C13—N3 | 178.90 (9) |
C3—C4—C5—C6 | 179.48 (9) | C1—N1—C16—C17 | 103.20 (12) |
C9—C4—C5—N1 | 178.54 (9) | C5—N1—C16—C17 | −78.11 (13) |
C3—C4—C5—N1 | −1.86 (15) | C1—N1—C16—C18 | 32.78 (14) |
N1—C5—C6—F1 | −4.25 (16) | C5—N1—C16—C18 | −148.53 (10) |
C4—C5—C6—F1 | 174.35 (9) | N1—C16—C17—C18 | −108.97 (11) |
N1—C5—C6—C7 | −179.91 (9) | N1—C16—C18—C17 | 109.14 (11) |
C4—C5—C6—C7 | −1.31 (16) | C1—C2—C19—O1 | 4.97 (16) |
C10—N3—C7—C8 | −141.61 (11) | C3—C2—C19—O1 | −174.97 (10) |
C13—N3—C7—C8 | 47.59 (15) | C1—C2—C19—O2 | −174.44 (10) |
C10—N3—C7—C6 | 39.09 (16) | C3—C2—C19—O2 | 5.62 (15) |
C13—N3—C7—C6 | −131.71 (11) | C25—C20—C21—C22 | 0.59 (17) |
F1—C6—C7—N3 | 4.61 (15) | C26—C20—C21—C22 | −176.77 (10) |
C5—C6—C7—N3 | −179.52 (10) | C20—C21—C22—C23 | 0.31 (18) |
F1—C6—C7—C8 | −174.73 (9) | C21—C22—C23—C24 | −0.65 (18) |
C5—C6—C7—C8 | 1.15 (16) | C22—C23—C24—C25 | 0.07 (17) |
N3—C7—C8—F2 | 2.55 (15) | C23—C24—C25—C20 | 0.85 (17) |
C6—C7—C8—F2 | −178.11 (9) | C21—C20—C25—C24 | −1.17 (16) |
N3—C7—C8—C9 | −178.87 (10) | C26—C20—C25—C24 | 176.2 (1) |
C6—C7—C8—C9 | 0.47 (16) | C25—C20—C26—C27 | 128.84 (11) |
F2—C8—C9—N2 | −2.14 (15) | C21—C20—C26—C27 | −53.85 (14) |
C7—C8—C9—N2 | 179.25 (10) | C20—C26—C27—O5 | 130.02 (11) |
F2—C8—C9—C4 | 176.79 (9) | C20—C26—C27—O4 | −51.32 (13) |
D—H···A | D—H | H···A | D···A | D—H···A |
O2—H2O···O3 | 0.95 (2) | 1.61 (2) | 2.5162 (12) | 157.3 (18) |
N2—H2NB···O3 | 0.900 (17) | 1.917 (16) | 2.6200 (13) | 133.6 (14) |
N4—H4NB···O4 | 0.949 (16) | 1.781 (16) | 2.7122 (12) | 166.3 (13) |
N2—H2NA···O5i | 0.869 (17) | 2.232 (17) | 2.9958 (13) | 146.5 (14) |
N4—H4NA···O4ii | 0.956 (16) | 1.834 (16) | 2.7580 (12) | 161.8 (14) |
Symmetry codes: (i) −x+1, −y+1, −z+2; (ii) −x+1, −y+1, −z+1. |
C19H23F2N4O3+·C8H7O2−·3H2O | F(000) = 1232 |
Mr = 582.60 | Dx = 1.411 Mg m−3 |
Monoclinic, P21/n | Mo Kα radiation, λ = 0.71073 Å |
a = 18.4423 (9) Å | Cell parameters from 9800 reflections |
b = 7.0694 (3) Å | θ = 2.9–27.5° |
c = 21.0669 (10) Å | µ = 0.11 mm−1 |
β = 93.252 (2)° | T = 90 K |
V = 2742.2 (2) Å3 | Tablet, pale yellow |
Z = 4 | 0.19 × 0.15 × 0.04 mm |
Bruker D8 Venture dual source diffractometer | 6296 independent reflections |
Radiation source: microsource | 5086 reflections with I > 2σ(I) |
Detector resolution: 7.41 pixels mm-1 | Rint = 0.043 |
φ and ω scans | θmax = 27.5°, θmin = 2.2° |
Absorption correction: multi-scan (SADABS; Krause et al., 2015) | h = −23→23 |
Tmin = 0.894, Tmax = 0.959 | k = −9→9 |
44990 measured reflections | l = −27→27 |
Refinement on F2 | Secondary atom site location: difference Fourier map |
Least-squares matrix: full | Hydrogen site location: mixed |
R[F2 > 2σ(F2)] = 0.040 | H atoms treated by a mixture of independent and constrained refinement |
wR(F2) = 0.100 | w = 1/[σ2(Fo2) + (0.040P)2 + 1.6577P] where P = (Fo2 + 2Fc2)/3 |
S = 1.04 | (Δ/σ)max = 0.001 |
6296 reflections | Δρmax = 0.31 e Å−3 |
418 parameters | Δρmin = −0.23 e Å−3 |
0 restraints | Extinction correction: SHELXL-2019/2 (Sheldrick, 2015b), Fc*=kFc[1+0.001xFc2λ3/sin(2θ)]-1/4 |
Primary atom site location: structure-invariant direct methods | Extinction coefficient: 0.0021 (5) |
Experimental. The crystal was mounted using polyisobutene oil on the tip of a fine glass fibre, which was fastened in a copper mounting pin with electrical solder. It was placed directly into the cold gas stream of a liquid-nitrogen based cryostat (Hope, 1994; Parkin & Hope, 1998). Diffraction data were collected with the crystal at 90K, which is standard practice in this laboratory for the majority of flash-cooled crystals. |
Geometry. All esds (except the esd in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell esds are taken into account individually in the estimation of esds in distances, angles and torsion angles; correlations between esds in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell esds is used for estimating esds involving l.s. planes. |
Refinement. Refinement progress was checked using Platon (Spek, 2020) and by an R-tensor (Parkin, 2000). The final model was further checked with the IUCr utility checkCIF. |
x | y | z | Uiso*/Ueq | ||
F1 | 0.16930 (4) | 0.64545 (14) | 0.41384 (4) | 0.0232 (2) | |
F2 | 0.19188 (4) | 0.74700 (13) | 0.63429 (4) | 0.0213 (2) | |
O1 | −0.20441 (5) | 0.79723 (16) | 0.41468 (5) | 0.0235 (2) | |
O2 | −0.19618 (5) | 0.87221 (15) | 0.51703 (5) | 0.0202 (2) | |
H2O | −0.1594 (12) | 0.877 (3) | 0.5482 (10) | 0.044 (6)* | |
O3 | −0.07638 (5) | 0.84435 (15) | 0.57818 (5) | 0.0189 (2) | |
N1 | 0.01575 (6) | 0.68755 (17) | 0.41300 (5) | 0.0142 (2) | |
N2 | 0.05167 (7) | 0.8265 (2) | 0.64025 (6) | 0.0213 (3) | |
H2NA | 0.0811 (11) | 0.828 (3) | 0.6762 (10) | 0.034 (5)* | |
H2NB | 0.0031 (12) | 0.843 (3) | 0.6419 (10) | 0.042 (6)* | |
N3 | 0.25676 (6) | 0.66015 (18) | 0.52407 (6) | 0.0177 (3) | |
N4 | 0.40460 (6) | 0.56168 (18) | 0.54358 (6) | 0.0147 (2) | |
H4NA | 0.4412 (10) | 0.495 (3) | 0.5696 (9) | 0.029 (5)* | |
H4NB | 0.4268 (10) | 0.618 (3) | 0.5108 (10) | 0.034 (5)* | |
C1 | −0.05565 (7) | 0.7201 (2) | 0.41541 (7) | 0.0152 (3) | |
H1 | −0.085398 | 0.704074 | 0.377484 | 0.018* | |
C2 | −0.08820 (7) | 0.7749 (2) | 0.46899 (7) | 0.0151 (3) | |
C3 | −0.04622 (7) | 0.79463 (19) | 0.52777 (7) | 0.0147 (3) | |
C4 | 0.03060 (7) | 0.75619 (19) | 0.52685 (7) | 0.0140 (3) | |
C5 | 0.06170 (7) | 0.70427 (19) | 0.46870 (6) | 0.0138 (3) | |
C6 | 0.13643 (7) | 0.6767 (2) | 0.46875 (7) | 0.0152 (3) | |
C7 | 0.18246 (7) | 0.6910 (2) | 0.52359 (7) | 0.0152 (3) | |
C8 | 0.15010 (7) | 0.7376 (2) | 0.57941 (7) | 0.0161 (3) | |
C9 | 0.07665 (7) | 0.7750 (2) | 0.58355 (7) | 0.0151 (3) | |
C10 | 0.28872 (7) | 0.5277 (2) | 0.48072 (7) | 0.0161 (3) | |
H10A | 0.307178 | 0.597178 | 0.444152 | 0.019* | |
H10B | 0.251383 | 0.436797 | 0.464287 | 0.019* | |
C11 | 0.35064 (7) | 0.4220 (2) | 0.51562 (7) | 0.0155 (3) | |
H11 | 0.330677 | 0.346821 | 0.550866 | 0.019* | |
C12 | 0.37170 (7) | 0.7063 (2) | 0.58566 (7) | 0.0156 (3) | |
H12 | 0.353367 | 0.640709 | 0.623632 | 0.019* | |
C13 | 0.30834 (7) | 0.8012 (2) | 0.54943 (7) | 0.0160 (3) | |
H13A | 0.283667 | 0.887997 | 0.578133 | 0.019* | |
H13B | 0.326437 | 0.876885 | 0.514093 | 0.019* | |
C14 | 0.43038 (8) | 0.8463 (2) | 0.60792 (7) | 0.0209 (3) | |
H14A | 0.449360 | 0.909818 | 0.570983 | 0.031* | |
H14B | 0.469877 | 0.778736 | 0.631283 | 0.031* | |
H14C | 0.409720 | 0.940576 | 0.635826 | 0.031* | |
C15 | 0.38846 (8) | 0.2884 (2) | 0.47176 (7) | 0.0206 (3) | |
H15A | 0.353957 | 0.192234 | 0.455446 | 0.031* | |
H15B | 0.429211 | 0.226688 | 0.495390 | 0.031* | |
H15C | 0.406627 | 0.360047 | 0.436145 | 0.031* | |
C16 | 0.04298 (7) | 0.6192 (2) | 0.35325 (7) | 0.0163 (3) | |
H16 | 0.062144 | 0.486827 | 0.354403 | 0.020* | |
C17 | 0.08061 (8) | 0.7518 (2) | 0.31081 (7) | 0.0218 (3) | |
H17A | 0.122153 | 0.702225 | 0.288103 | 0.026* | |
H17B | 0.085039 | 0.885832 | 0.324048 | 0.026* | |
C18 | 0.00625 (8) | 0.6788 (3) | 0.29126 (7) | 0.0264 (4) | |
H18A | −0.035058 | 0.767882 | 0.292530 | 0.032* | |
H18B | 0.002063 | 0.584243 | 0.256578 | 0.032* | |
C19 | −0.16741 (7) | 0.8147 (2) | 0.46384 (7) | 0.0173 (3) | |
O4 | 0.48721 (6) | 0.37218 (16) | 0.63034 (5) | 0.0225 (2) | |
O5 | 0.55454 (5) | 0.23301 (15) | 0.55920 (5) | 0.0191 (2) | |
C20 | 0.59698 (7) | 0.2240 (2) | 0.66740 (7) | 0.0146 (3) | |
C21 | 0.58790 (8) | 0.2764 (2) | 0.73007 (7) | 0.0169 (3) | |
H21 | 0.544617 | 0.338837 | 0.740721 | 0.020* | |
C22 | 0.64159 (8) | 0.2383 (2) | 0.77720 (7) | 0.0171 (3) | |
H22 | 0.634344 | 0.274197 | 0.819832 | 0.021* | |
C23 | 0.70593 (8) | 0.1483 (2) | 0.76303 (7) | 0.0166 (3) | |
C24 | 0.71450 (8) | 0.0948 (2) | 0.70020 (7) | 0.0173 (3) | |
H24 | 0.757892 | 0.033059 | 0.689484 | 0.021* | |
C25 | 0.66076 (8) | 0.1303 (2) | 0.65326 (7) | 0.0172 (3) | |
H25 | 0.667292 | 0.090469 | 0.610891 | 0.021* | |
C26 | 0.54199 (7) | 0.2778 (2) | 0.61474 (7) | 0.0159 (3) | |
C27 | 0.76456 (8) | 0.1112 (2) | 0.81411 (7) | 0.0209 (3) | |
H27A | 0.765320 | −0.023819 | 0.824717 | 0.031* | |
H27B | 0.754839 | 0.184994 | 0.852067 | 0.031* | |
H27C | 0.811717 | 0.148138 | 0.798799 | 0.031* | |
O1W | 0.29379 (6) | 0.11084 (17) | 0.69541 (6) | 0.0268 (3) | |
H1W1 | 0.3314 (14) | 0.219 (4) | 0.7047 (12) | 0.064 (7)* | |
H2W1 | 0.2678 (15) | 0.150 (4) | 0.6565 (14) | 0.077 (9)* | |
O2W | 0.39349 (6) | 0.39000 (18) | 0.72635 (5) | 0.0236 (2) | |
H1W2 | 0.3732 (13) | 0.510 (4) | 0.7276 (11) | 0.060 (7)* | |
H2W2 | 0.4297 (13) | 0.386 (4) | 0.6967 (12) | 0.058 (7)* | |
O3W | 0.32955 (6) | 0.73767 (19) | 0.74222 (6) | 0.0302 (3) | |
H1W3 | 0.2830 (13) | 0.702 (4) | 0.7636 (11) | 0.057 (7)* | |
H2W3 | 0.3180 (17) | 0.868 (5) | 0.7265 (15) | 0.100 (11)* |
U11 | U22 | U33 | U12 | U13 | U23 | |
F1 | 0.0146 (4) | 0.0418 (6) | 0.0133 (4) | 0.0048 (4) | 0.0013 (3) | −0.0019 (4) |
F2 | 0.0176 (4) | 0.0310 (5) | 0.0147 (4) | 0.0010 (4) | −0.0054 (3) | −0.0021 (4) |
O1 | 0.0155 (5) | 0.0304 (6) | 0.0241 (6) | 0.0022 (5) | −0.0036 (4) | −0.0007 (5) |
O2 | 0.0143 (5) | 0.0240 (6) | 0.0224 (6) | 0.0014 (4) | 0.0015 (4) | 0.0000 (4) |
O3 | 0.0168 (5) | 0.0245 (6) | 0.0157 (5) | 0.0019 (4) | 0.0030 (4) | 0.0003 (4) |
N1 | 0.0139 (5) | 0.0158 (6) | 0.0127 (6) | 0.0002 (5) | −0.0002 (4) | 0.0003 (5) |
N2 | 0.0174 (6) | 0.0331 (8) | 0.0132 (6) | 0.0015 (6) | 0.0001 (5) | −0.0029 (5) |
N3 | 0.0124 (5) | 0.0200 (6) | 0.0204 (6) | 0.0009 (5) | −0.0019 (5) | −0.0050 (5) |
N4 | 0.0131 (5) | 0.0173 (6) | 0.0136 (6) | 0.0009 (5) | −0.0008 (5) | −0.0009 (5) |
C1 | 0.0140 (6) | 0.0134 (6) | 0.0176 (7) | −0.0004 (5) | −0.0028 (5) | 0.0021 (5) |
C2 | 0.0130 (6) | 0.0147 (7) | 0.0174 (7) | 0.0001 (5) | −0.0002 (5) | 0.0024 (5) |
C3 | 0.0160 (6) | 0.0111 (6) | 0.0171 (7) | −0.0008 (5) | 0.0006 (5) | 0.0031 (5) |
C4 | 0.0145 (6) | 0.0122 (6) | 0.0152 (7) | −0.0007 (5) | 0.0001 (5) | 0.0012 (5) |
C5 | 0.0144 (6) | 0.0127 (6) | 0.0139 (7) | −0.0013 (5) | −0.0015 (5) | 0.0016 (5) |
C6 | 0.0158 (6) | 0.0172 (7) | 0.0127 (6) | 0.0003 (5) | 0.0024 (5) | 0.0001 (5) |
C7 | 0.0130 (6) | 0.0141 (7) | 0.0182 (7) | 0.0004 (5) | −0.0010 (5) | 0.0010 (5) |
C8 | 0.0166 (7) | 0.0180 (7) | 0.0132 (7) | −0.0010 (5) | −0.0047 (5) | 0.0011 (5) |
C9 | 0.0168 (7) | 0.0143 (7) | 0.0142 (7) | −0.0012 (5) | 0.0003 (5) | 0.0012 (5) |
C10 | 0.0147 (6) | 0.0175 (7) | 0.0160 (7) | −0.0004 (5) | −0.0013 (5) | −0.0029 (6) |
C11 | 0.0143 (6) | 0.0149 (7) | 0.0171 (7) | −0.0013 (5) | −0.0007 (5) | −0.0003 (5) |
C12 | 0.0148 (6) | 0.0191 (7) | 0.0127 (6) | 0.0007 (6) | 0.0003 (5) | −0.0021 (6) |
C13 | 0.0143 (6) | 0.0164 (7) | 0.0171 (7) | −0.0002 (5) | −0.0009 (5) | −0.0022 (6) |
C14 | 0.0158 (7) | 0.0251 (8) | 0.0215 (8) | −0.0008 (6) | −0.0019 (6) | −0.0067 (6) |
C15 | 0.0199 (7) | 0.0189 (7) | 0.0229 (8) | 0.0025 (6) | −0.0007 (6) | −0.0042 (6) |
C16 | 0.0163 (6) | 0.0177 (7) | 0.0147 (7) | 0.0017 (5) | −0.0008 (5) | −0.0020 (5) |
C17 | 0.0234 (7) | 0.0245 (8) | 0.0180 (7) | 0.0036 (6) | 0.0040 (6) | 0.0041 (6) |
C18 | 0.0223 (7) | 0.0419 (10) | 0.0148 (7) | 0.0071 (7) | −0.0009 (6) | 0.0002 (7) |
C19 | 0.0154 (7) | 0.0166 (7) | 0.0200 (7) | −0.0004 (6) | 0.0015 (5) | 0.0021 (6) |
O4 | 0.0197 (5) | 0.0300 (6) | 0.0174 (5) | 0.0076 (5) | −0.0009 (4) | 0.0015 (5) |
O5 | 0.0201 (5) | 0.0236 (6) | 0.0135 (5) | −0.0011 (4) | −0.0011 (4) | 0.0008 (4) |
C20 | 0.0158 (6) | 0.0138 (6) | 0.0139 (7) | −0.0016 (5) | −0.0008 (5) | 0.0012 (5) |
C21 | 0.0153 (6) | 0.0191 (7) | 0.0164 (7) | 0.0003 (6) | 0.0013 (5) | 0.0005 (6) |
C22 | 0.0199 (7) | 0.0180 (7) | 0.0135 (7) | −0.0009 (6) | 0.0010 (5) | 0.0003 (6) |
C23 | 0.0185 (7) | 0.0137 (7) | 0.0172 (7) | −0.0014 (5) | −0.0015 (5) | 0.0032 (5) |
C24 | 0.0176 (7) | 0.0149 (7) | 0.0194 (7) | 0.0030 (6) | 0.0007 (6) | 0.0010 (6) |
C25 | 0.0211 (7) | 0.0151 (7) | 0.0152 (7) | −0.0003 (6) | 0.0012 (5) | −0.0004 (6) |
C26 | 0.0160 (6) | 0.0158 (7) | 0.0159 (7) | −0.0024 (5) | −0.0002 (5) | 0.0027 (5) |
C27 | 0.0225 (7) | 0.0212 (7) | 0.0184 (7) | 0.0025 (6) | −0.0041 (6) | 0.0018 (6) |
O1W | 0.0254 (6) | 0.0285 (6) | 0.0262 (6) | 0.0007 (5) | −0.0017 (5) | −0.0008 (5) |
O2W | 0.0219 (5) | 0.0287 (6) | 0.0201 (6) | 0.0018 (5) | 0.0008 (4) | 0.0019 (5) |
O3W | 0.0257 (6) | 0.0307 (7) | 0.0349 (7) | 0.0040 (5) | 0.0072 (5) | 0.0039 (5) |
F1—C6 | 1.3541 (16) | C13—H13B | 0.9900 |
F2—C8 | 1.3540 (15) | C14—H14A | 0.9800 |
O1—C19 | 1.2138 (18) | C14—H14B | 0.9800 |
O2—C19 | 1.3305 (18) | C14—H14C | 0.9800 |
O2—H2O | 0.92 (2) | C15—H15A | 0.9800 |
O3—C3 | 1.2758 (17) | C15—H15B | 0.9800 |
N1—C1 | 1.3404 (17) | C15—H15C | 0.9800 |
N1—C5 | 1.4129 (17) | C16—C17 | 1.493 (2) |
N1—C16 | 1.4636 (18) | C16—C18 | 1.497 (2) |
N2—C9 | 1.3542 (19) | C16—H16 | 1.0000 |
N2—H2NA | 0.91 (2) | C17—C18 | 1.501 (2) |
N2—H2NB | 0.91 (2) | C17—H17A | 0.9900 |
N3—C7 | 1.3870 (17) | C17—H17B | 0.9900 |
N3—C10 | 1.4558 (18) | C18—H18A | 0.9900 |
N3—C13 | 1.4585 (18) | C18—H18B | 0.9900 |
N4—C11 | 1.4987 (18) | O4—C26 | 1.2692 (18) |
N4—C12 | 1.5036 (18) | O5—C26 | 1.2465 (17) |
N4—H4NA | 0.967 (19) | C20—C21 | 1.391 (2) |
N4—H4NB | 0.91 (2) | C20—C25 | 1.397 (2) |
C1—C2 | 1.364 (2) | C20—C26 | 1.5089 (19) |
C1—H1 | 0.9500 | C21—C22 | 1.388 (2) |
C2—C3 | 1.4296 (19) | C21—H21 | 0.9500 |
C2—C19 | 1.4855 (19) | C22—C23 | 1.394 (2) |
C3—C4 | 1.4438 (19) | C22—H22 | 0.9500 |
C4—C5 | 1.4298 (19) | C23—C24 | 1.394 (2) |
C4—C9 | 1.4321 (19) | C23—C27 | 1.5045 (19) |
C5—C6 | 1.3920 (19) | C24—C25 | 1.383 (2) |
C6—C7 | 1.3980 (19) | C24—H24 | 0.9500 |
C7—C8 | 1.388 (2) | C25—H25 | 0.9500 |
C8—C9 | 1.3877 (19) | C27—H27A | 0.9800 |
C10—C11 | 1.5193 (19) | C27—H27B | 0.9800 |
C10—H10A | 0.9900 | C27—H27C | 0.9800 |
C10—H10B | 0.9900 | O1W—H1W1 | 1.04 (3) |
C11—C15 | 1.518 (2) | O1W—H2W1 | 0.96 (3) |
C11—H11 | 1.0000 | O2W—H1W2 | 0.93 (3) |
C12—C13 | 1.5155 (19) | O2W—H2W2 | 0.94 (3) |
C12—C14 | 1.521 (2) | O3W—H1W3 | 1.02 (3) |
C12—H12 | 1.0000 | O3W—H2W3 | 1.00 (4) |
C13—H13A | 0.9900 | ||
C19—O2—H2O | 107.5 (14) | C12—C13—H13B | 109.6 |
C1—N1—C5 | 119.89 (12) | H13A—C13—H13B | 108.1 |
C1—N1—C16 | 118.36 (11) | C12—C14—H14A | 109.5 |
C5—N1—C16 | 121.53 (11) | C12—C14—H14B | 109.5 |
C9—N2—H2NA | 121.5 (12) | H14A—C14—H14B | 109.5 |
C9—N2—H2NB | 117.1 (13) | C12—C14—H14C | 109.5 |
H2NA—N2—H2NB | 120.8 (18) | H14A—C14—H14C | 109.5 |
C7—N3—C10 | 122.11 (12) | H14B—C14—H14C | 109.5 |
C7—N3—C13 | 121.25 (12) | C11—C15—H15A | 109.5 |
C10—N3—C13 | 113.00 (11) | C11—C15—H15B | 109.5 |
C11—N4—C12 | 113.50 (11) | H15A—C15—H15B | 109.5 |
C11—N4—H4NA | 109.2 (11) | C11—C15—H15C | 109.5 |
C12—N4—H4NA | 106.8 (11) | H15A—C15—H15C | 109.5 |
C11—N4—H4NB | 107.8 (12) | H15B—C15—H15C | 109.5 |
C12—N4—H4NB | 111.4 (13) | N1—C16—C17 | 120.10 (13) |
H4NA—N4—H4NB | 108.1 (16) | N1—C16—C18 | 119.79 (12) |
N1—C1—C2 | 124.01 (13) | C17—C16—C18 | 60.25 (10) |
N1—C1—H1 | 118.0 | N1—C16—H16 | 115.2 |
C2—C1—H1 | 118.0 | C17—C16—H16 | 115.2 |
C1—C2—C3 | 120.15 (12) | C18—C16—H16 | 115.2 |
C1—C2—C19 | 118.06 (13) | C16—C17—C18 | 60.0 (1) |
C3—C2—C19 | 121.78 (13) | C16—C17—H17A | 117.8 |
O3—C3—C2 | 120.51 (12) | C18—C17—H17A | 117.8 |
O3—C3—C4 | 122.51 (13) | C16—C17—H17B | 117.8 |
C2—C3—C4 | 116.98 (12) | C18—C17—H17B | 117.8 |
C5—C4—C9 | 119.40 (12) | H17A—C17—H17B | 114.9 |
C5—C4—C3 | 120.09 (12) | C16—C18—C17 | 59.75 (10) |
C9—C4—C3 | 120.49 (13) | C16—C18—H18A | 117.8 |
C6—C5—N1 | 122.42 (12) | C17—C18—H18A | 117.8 |
C6—C5—C4 | 118.73 (12) | C16—C18—H18B | 117.8 |
N1—C5—C4 | 118.83 (12) | C17—C18—H18B | 117.8 |
F1—C6—C5 | 120.90 (12) | H18A—C18—H18B | 114.9 |
F1—C6—C7 | 115.95 (12) | O1—C19—O2 | 121.19 (13) |
C5—C6—C7 | 123.03 (13) | O1—C19—C2 | 123.08 (13) |
N3—C7—C8 | 120.21 (12) | O2—C19—C2 | 115.72 (12) |
N3—C7—C6 | 123.22 (13) | C21—C20—C25 | 118.51 (13) |
C8—C7—C6 | 116.57 (12) | C21—C20—C26 | 121.24 (13) |
F2—C8—C9 | 116.56 (12) | C25—C20—C26 | 120.12 (13) |
F2—C8—C7 | 118.93 (12) | C22—C21—C20 | 120.52 (13) |
C9—C8—C7 | 124.51 (13) | C22—C21—H21 | 119.7 |
N2—C9—C8 | 119.27 (13) | C20—C21—H21 | 119.7 |
N2—C9—C4 | 123.04 (13) | C21—C22—C23 | 121.13 (13) |
C8—C9—C4 | 117.69 (13) | C21—C22—H22 | 119.4 |
N3—C10—C11 | 109.43 (11) | C23—C22—H22 | 119.4 |
N3—C10—H10A | 109.8 | C22—C23—C24 | 118.09 (13) |
C11—C10—H10A | 109.8 | C22—C23—C27 | 120.84 (13) |
N3—C10—H10B | 109.8 | C24—C23—C27 | 121.07 (13) |
C11—C10—H10B | 109.8 | C25—C24—C23 | 120.97 (13) |
H10A—C10—H10B | 108.2 | C25—C24—H24 | 119.5 |
N4—C11—C15 | 109.35 (11) | C23—C24—H24 | 119.5 |
N4—C11—C10 | 109.27 (11) | C24—C25—C20 | 120.76 (13) |
C15—C11—C10 | 111.72 (12) | C24—C25—H25 | 119.6 |
N4—C11—H11 | 108.8 | C20—C25—H25 | 119.6 |
C15—C11—H11 | 108.8 | O5—C26—O4 | 124.71 (13) |
C10—C11—H11 | 108.8 | O5—C26—C20 | 118.24 (13) |
N4—C12—C13 | 109.24 (11) | O4—C26—C20 | 117.00 (12) |
N4—C12—C14 | 108.69 (11) | C23—C27—H27A | 109.5 |
C13—C12—C14 | 112.46 (12) | C23—C27—H27B | 109.5 |
N4—C12—H12 | 108.8 | H27A—C27—H27B | 109.5 |
C13—C12—H12 | 108.8 | C23—C27—H27C | 109.5 |
C14—C12—H12 | 108.8 | H27A—C27—H27C | 109.5 |
N3—C13—C12 | 110.49 (12) | H27B—C27—H27C | 109.5 |
N3—C13—H13A | 109.6 | H1W1—O1W—H2W1 | 104 (2) |
C12—C13—H13A | 109.6 | H1W2—O2W—H2W2 | 110 (2) |
N3—C13—H13B | 109.6 | H1W3—O3W—H2W3 | 102 (2) |
C5—N1—C1—C2 | 1.9 (2) | C5—C4—C9—N2 | 178.94 (13) |
C16—N1—C1—C2 | 176.62 (13) | C3—C4—C9—N2 | 0.8 (2) |
N1—C1—C2—C3 | −2.2 (2) | C5—C4—C9—C8 | −1.3 (2) |
N1—C1—C2—C19 | 177.15 (13) | C3—C4—C9—C8 | −179.45 (13) |
C1—C2—C3—O3 | −179.45 (13) | C7—N3—C10—C11 | −140.81 (13) |
C19—C2—C3—O3 | 1.3 (2) | C13—N3—C10—C11 | 60.49 (15) |
C1—C2—C3—C4 | 0.6 (2) | C12—N4—C11—C15 | 177.44 (12) |
C19—C2—C3—C4 | −178.66 (12) | C12—N4—C11—C10 | 54.87 (15) |
O3—C3—C4—C5 | −178.86 (13) | N3—C10—C11—N4 | −56.09 (15) |
C2—C3—C4—C5 | 1.06 (19) | N3—C10—C11—C15 | −177.22 (12) |
O3—C3—C4—C9 | −0.7 (2) | C11—N4—C12—C13 | −53.64 (15) |
C2—C3—C4—C9 | 179.20 (13) | C11—N4—C12—C14 | −176.68 (12) |
C1—N1—C5—C6 | −178.40 (13) | C7—N3—C13—C12 | 141.28 (13) |
C16—N1—C5—C6 | 7.0 (2) | C10—N3—C13—C12 | −59.81 (16) |
C1—N1—C5—C4 | −0.05 (19) | N4—C12—C13—N3 | 54.01 (15) |
C16—N1—C5—C4 | −174.64 (12) | C14—C12—C13—N3 | 174.77 (12) |
C9—C4—C5—C6 | −1.1 (2) | C1—N1—C16—C17 | 102.71 (15) |
C3—C4—C5—C6 | 177.05 (13) | C5—N1—C16—C17 | −82.62 (17) |
C9—C4—C5—N1 | −179.52 (12) | C1—N1—C16—C18 | 31.9 (2) |
C3—C4—C5—N1 | −1.36 (19) | C5—N1—C16—C18 | −153.41 (14) |
N1—C5—C6—F1 | 4.8 (2) | N1—C16—C17—C18 | −109.28 (15) |
C4—C5—C6—F1 | −173.55 (12) | N1—C16—C18—C17 | 109.78 (15) |
N1—C5—C6—C7 | −179.38 (13) | C1—C2—C19—O1 | 1.4 (2) |
C4—C5—C6—C7 | 2.3 (2) | C3—C2—C19—O1 | −179.26 (14) |
C10—N3—C7—C8 | 148.72 (14) | C1—C2—C19—O2 | −178.35 (13) |
C13—N3—C7—C8 | −54.31 (19) | C3—C2—C19—O2 | 1.0 (2) |
C10—N3—C7—C6 | −30.9 (2) | C25—C20—C21—C22 | 0.8 (2) |
C13—N3—C7—C6 | 126.05 (15) | C26—C20—C21—C22 | −175.08 (13) |
F1—C6—C7—N3 | −5.2 (2) | C20—C21—C22—C23 | 0.5 (2) |
C5—C6—C7—N3 | 178.76 (13) | C21—C22—C23—C24 | −1.0 (2) |
F1—C6—C7—C8 | 175.12 (12) | C21—C22—C23—C27 | 178.68 (14) |
C5—C6—C7—C8 | −0.9 (2) | C22—C23—C24—C25 | 0.1 (2) |
N3—C7—C8—F2 | −1.9 (2) | C27—C23—C24—C25 | −179.53 (14) |
C6—C7—C8—F2 | 177.78 (12) | C23—C24—C25—C20 | 1.2 (2) |
N3—C7—C8—C9 | 178.56 (13) | C21—C20—C25—C24 | −1.6 (2) |
C6—C7—C8—C9 | −1.8 (2) | C26—C20—C25—C24 | 174.28 (13) |
F2—C8—C9—N2 | 3.0 (2) | C21—C20—C26—O5 | 177.27 (13) |
C7—C8—C9—N2 | −177.39 (14) | C25—C20—C26—O5 | 1.5 (2) |
F2—C8—C9—C4 | −176.72 (12) | C21—C20—C26—O4 | −0.3 (2) |
C7—C8—C9—C4 | 2.8 (2) | C25—C20—C26—O4 | −176.07 (13) |
D—H···A | D—H | H···A | D···A | D—H···A |
O2—H2O···O3 | 0.92 (2) | 1.64 (2) | 2.5014 (14) | 155 (2) |
N2—H2NB···O3 | 0.91 (2) | 1.93 (2) | 2.6367 (17) | 133.4 (18) |
N4—H4NA···O4 | 0.967 (19) | 1.73 (2) | 2.6722 (16) | 164.1 (17) |
N4—H4NB···O5i | 0.91 (2) | 1.86 (2) | 2.7473 (16) | 163.0 (18) |
N2—H2NA···O2Wii | 0.91 (2) | 2.12 (2) | 2.9664 (17) | 153.9 (17) |
O2W—H2W2···O4 | 0.94 (3) | 1.80 (3) | 2.7371 (16) | 171 (2) |
O1W—H1W1···O2W | 1.04 (3) | 1.71 (3) | 2.7503 (17) | 175 (2) |
O2W—H1W2···O3W | 0.93 (3) | 1.83 (3) | 2.7546 (18) | 171 (2) |
O1W—H2W1···O1iii | 0.96 (3) | 1.89 (3) | 2.8434 (16) | 171 (2) |
O3W—H1W3···O1Wii | 1.02 (3) | 1.82 (3) | 2.8362 (17) | 173 (2) |
O3W—H2W3···O1Wiv | 1.00 (4) | 1.88 (4) | 2.8798 (18) | 178 (3) |
Symmetry codes: (i) −x+1, −y+1, −z+1; (ii) −x+1/2, y+1/2, −z+3/2; (iii) −x, −y+1, −z+1; (iv) x, y+1, z. |
Atom contacts | I | II | III |
H···H | 41.2 | 40.3 | 48.0 |
H···O | 28.8 | 25.5 | 23.4 |
H···C | 10.0 | 15.5 | 7.9 |
C···C | 6.0 | 4.6 | 7.7 |
H···F | 3.5 | 7.7 | 5.7 |
O···F | 2.6 | 0.2 | 1.3 |
C···O | 2.3 | 1.4 | 2.5 |
H···N | 1.6 | 3.0 | 1.5 |
Heterogeneous contact types here include the reciprocal interactions, e.g., "H···O" represents "H···O/O···H". All other fractions of atom-contact coverages were negligible. |