Figure 9
Conformational change of the myosin heads (subfragment-1, S1) in the presence of ATP. (a) The comparison of the X-ray solution scattering curves taken from S1 samples with no nucleotide and in the presence of MgATP. In this plot the deviation of the scattering curve of S1 in ATP solution from that with no nucleotide beyond SRg = 0.4 (where Rg is the radius of gyration of S1) shows the distinct shape change during hydrolysis of ATP. (b) Modelling of the conformational change of S1 in the presence of ATP by using the atomic data of S1. When the two models are coincided with their N-terminus of the proximal domain (the catalytic domain), the distal tip of the molecule moves as shown by the arrows (vertically and azimuthally). In this figure the imaginary actin filament axis is aligned vertically in the left-hand side of the models. |