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Figure 1
Generic protein phase diagram. Protein solubility and supersolubility vary as a function of a physical parameter such as temperature or a chemical parameter such as salt concentration or pH. Clearly, crystallization of the protein will not occur in the region of phase space below the solubility limit but from a supersaturated solution. However, if protein precipitates rapidly, large single crystals are not likely to form from the precipitate; hence, crystallization experiments should be designed to equilibrate in the metastable region above the solubility limit and below the supersolubility limit.

Journal logoJOURNAL OF
SYNCHROTRON
RADIATION
ISSN: 1600-5775
Volume 12| Part 6| October 2005| Pages 779-785
doi:10.1107/S0909049505002621
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