Key steps in the structure-based optimization of the hepatitis C virus NS3/4A protease inhibitor SCH503034

Madison, V.; Prongay, A.J.; Guo, Z.; Yao, N.; Pichardo, J.; Fischmann, T.; Strickland, C.; Myers Jr, J.; Weber, P.C.; Beyer, B.M.; Ingram, R.; Hong, Z.; Prosise, W.W.; Ramanathan, L.; Taremi, S.S.; Yarosh-Tomaine, T.; Zhang, R.; Senior, M.; Yang, R.-S.; Malcolm, B.; Arasappan, A.; Bennett, F.; Bogen, S.L.; Chen, K.; Jao, E.; Liu, Y.-T.; Lovey, R.G.; Saksena, A.K.; Venkatraman, S.; Girijavallabhan, V.; Njoroge, F.G.

doi:10.1107/S0909049507064229

Journal of Synchrotron Radiation Journal of
Synchrotron Radiation

IUCr IT WDC

home archive editors for authors for readers submit subscribe open access

view article

Figure 1
Crystal structure of the covalent complex between 9 and the protease. The protein surface is shown with the inhibitor in ball and stick representation, with atom colors as follows: protein C atoms, white; inhibitor C atoms, green; polar H atoms, cyan; N atoms, blue; O atoms, red; sulfur, yellow. The figure was generated using Pymol (Delano, 2002

JOURNAL OF
SYNCHROTRON
RADIATION

ISSN: 1600-5775

Volume 15| Part 3| May 2008| Pages 204-207

https://doi.org/10.1107/S0909049507064229

Open

access

Follow J. Synchrotron Rad.

Search IUCr Journals		doi		Advanced search
Author		volume	page