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Figure 2
Three-dimensional reconstruction of the voltage-sensitive sodium channel from cryo-EM images. (a) Raw images of the sodium channel with different Euler angles. (b) Corresponding class averages (two-dimensional averages) for each raw image. An improved signal-to-noise ratio revealed characteristic views of the sodium channel. (c) Corresponding projection images from the three-dimensional structure and (d) surface views of the three-dimensional reconstruction. (e) EM of negatively stained sodium channel–antibody complexes. The cytoplasmic region was assigned by the binding of the antibody against the N-terminal sequence of the channel protein. The densities of the channel proteins and antibodies are indicated in the figures by ch and Ab, respectively. The scale bars represent 50 Å.

Journal logoJOURNAL OF
SYNCHROTRON
RADIATION
ISSN: 1600-5775
Volume 15| Part 3| May 2008| Pages 211-214
https://doi.org/10.1107/S0909049508004640
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