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Figure 3
Structures of (a) the voltage-sensitive sodium channel, (b) the type-1 IP3 receptor and (c) the TRPC3 channel. Surface-rendered representations of the reconstructed 6-TM cation channels are shown on the left of each part of the figure. The putative transmembrane zone is indicated by two blue lines approximately 30 Å apart. The predicted membrane topologies of these channels are represented with loops and terminal extensions in the top right of each part. Estimated volumes for the extracellular (or luminal), transmembrane and cytoplasmic domains are also indicated. Sections parallel to the membrane plane through the density maps are shown in the bottom right of each part. The positions marked by numbers 1–4 correspond to the numbers on the right-hand side of the surface-rendered representations. The scale bars represent 100 Å.

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