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Figure 4
Three possible binding models between TRPC3 and type-1 IP3 receptor. (a) Top-to-top binding at the center of both channels. The large dimensions of TRPC3 (green) imply a possible top-to-top binding with IP3R1 (brown), although a conformational change is needed for their close contact. The large space between the two membranes enables simultaneous association between TRPC3 and macromolecules including IP3R1 and PLCγ (Kiselyov et al., 1998BB12; Nishida et al., 2003BB21; van Rossum et al., 2005BB32). (b) Corner binding reduces the space between the membranes. (c) Side-by-side binding results in the narrowest membrane distance.

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