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Figure 1
Number of photons required to see a 50 nm-thick protein structure in either air or 50 nm of water (Hornberger et al., 2006BB13). The calculation is based on a simple projection (for absorption) and refraction [for differential phase contrast (DPC)] model with photon statistics as the only noise source. It applies the Rose criterion of a minimum signal-to-noise ratio of five for the detectability of features (Rose, 1946BB29). Atomic scattering data from Henke et al. (1993BB10).

Journal logoJOURNAL OF
SYNCHROTRON
RADIATION
ISSN: 1600-5775
Volume 15| Part 4| May 2008| Pages 355-362
doi:10.1107/S0909049508008509
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