Figure 2
Iodine location at the subcellular level determined by SIMS analysis. The F98 glioma-bearing rat received an intratumoral injection of IUdR during six days by means of osmotic pump. Panel (a) corresponds to a light microscopy view of a brain section stained with toluidine blue. The boxed part in panel (a) is the tumor brain area chosen for SIMS analysis. The panels (b), (c), (d) and (e) represent the corresponding SIMS analysis of CN−, P−, S− and I− ions, respectively, in this tumor brain area. Grey scale: white corresponds to low concentrations or the absence of the ion detected; black corresponds to high concentrations of the ion detected. |