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Figure 2
Cu K-edge microXANES from untreated and disulfiram (DSF)-treated breast tumor tissue. Normal kidney and liver tissue (from the same animals: DSF-treated and untreated) were also measured. The pre-edge peak at 8930 eV indicates a predominant Cu(I) status in all cases. There is a small but noticeable drop in intensity of the pre-edge peak in DSF-treated tumor compared with untreated tumor and to liver and kidney tissues (solvent and DSF-treated). This change suggests that DSF interacted actively and selectively with Cu tumor cells. Kidney and liver tissue spectra show no variation, suggesting DSF does not interact with Cu in normal tissue.

Journal logoJOURNAL OF
SYNCHROTRON
RADIATION
ISSN: 1600-5775
Volume 17| Part 4| May 2010| Pages 522-529
doi:10.1107/S0909049510016869
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