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Figure 1
Triggering mechanism: self-association of acylated insulin analogues begins from the T6 state upon removal of phenol. In the presence and absence of phenol the insulin hexamer exists in the relaxed (R6) and the tense state (T6), respectively. The major change happens in the N-terminal of the B-chain (red), which adopts different conformations in the two states. Zinc ions (black) coordinate insulin monomers in the central axis of the hexamer. The human insulin analogue is acylated at LysB29. LysB29 and the acylations (side chains) are not shown in this figure.

Journal logoJOURNAL OF
SYNCHROTRON
RADIATION
ISSN: 1600-5775
Volume 17| Part 6| September 2010| Pages 769-773
doi:10.1107/S0909049510030372
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