Figure 1
Data are expressed as the number of γ-H2AX foci per cell plotted against repair time post-irradiation. Each plot represents the mean ± standard errors of at least two independent replicates. (a) HMEC cells were pre-incubated for 24 h with 30 µM of platin, iodine (IUdR and iomeprol) or gadolinium. Immediately before the exposure to a total dose of 2 Gy 250 kV X-rays, the cell medium was renewed without drug. (b) The experimental protocols for curves in (a) and (b) were the same with the exception that the cell medium was not renewed in the (b) experiments and the photoactivatable drug was present during the irradiation and for an additional 24 h. Closed circles and open squares correspond to conditions without and with drugs, respectively. |