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Figure 3
Docking model of the Mtb Eis monomer with DUSP16/MKP-7. (a) Cartoon docking model of Mtb Eis monomer (PDB code 3ryo : green) and DUSP16/MKP-7 (PDB code 2vsw : yellow). Acetyl-CoA (blue) bound to Eis and Lys55 (magenta) of DUSP16/MKP-7 are shown as a ball-and-stick model. (b) Cartoon docking model of Mtb Eis dimer (PDB code 3ryo : green and cyan) and DUSP16/MKP-7 (PDB code 2vsw : yellow). Acetyl-CoA (blue) bound to Eis and Lys55 (red) of DUSP16/MKP-7 are shown as a ball-and-stick model. (c) The same monomer docking model is presented as an electrostatic surface diagram of Mtb Eis and a cartoon model of DUSP16/MKP-7. A black dotted circle indicates the active binding site of Mtb Eis. Both the cartoon model and electrostatic surface diagram of DUSP16/MKP-7 rotated by 180° are shown on a smaller scale. A red dotted circle indicates the binding site of DUSP16/MKP-7 with positive electrostatic potential. Blue and red colors of the electrostatic surface diagrams correspond to positive and negative electrostatic potentials at neutral pH, respectively.

Journal logoJOURNAL OF
SYNCHROTRON
RADIATION
ISSN: 1600-5775
Volume 20| Part 6| October 2013| Pages 929-932
doi:10.1107/S0909049513021341
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