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Figure 2
Reaction schemes for modification of side chains by [^\bullet]OH. The hydrocarbon side chain (of aliphatic non-polar and polar amino acids) predominantly undergoes hydrogen abstraction by [^\bullet]OH to give carbon-centered radicals, which then react with molecular O2 under aerobic conditions and subsequently form stable hydroxylated (+16 Da) or carbonylated (+14 Da) products. Aromatics and sulfur-containing side chains directly undergo hydroxylation by [^\bullet]OH followed by reaction with O2 under aerobic conditions to form stable hydroxylated products (+16 Da) and other oxygen adducts. Aromatics and sulfur-containing side chains can be labeled by 18O (red) from radiolysis of H218O water.

Journal logoJOURNAL OF
SYNCHROTRON
RADIATION
ISSN: 1600-5775
Volume 23| Part 5| September 2016| Pages 1056-1069
https://doi.org/10.1107/S1600577516009024
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