Analysis of the microvascular morphology and hemodynamics of breast cancer in mice using SPring-8 synchrotron radiation microangiography

Torii, M.; Fukui, T.; Inoue, M.; Kanao, S.; Umetani, K.; Shirai, M.; Inagaki, T.; Tsuchimochi, H.; Pearson, J.T.; Toi, M.

doi:10.1107/S1600577517008372

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Figure 6
Comparison of morphological parameters of microvessels between tumors prior to treatment (MDAMB231) and NOTCH4 overexpression tumor (MDAMB231^NOTCH4+) tissue. (a) The number of branches of each branch order is shown relative to the A0 origin (MDAMB231: n = 7; MDAMB231^NOTCH4+: n = 2). (b) The proportion of mice with more than A6 branches and less than A5 branches is presented. Mice with more than A6 branches were 8 out of 13 (61.5%) in MDAMB231-bearing mice and 7 out of 9 (87.5%) in MDAMB231^NOTCH4+-bearing mice. (c) The vessel diameter of MDAMB231 (n = 13) was 37.1 (9.2–140.1) and 27.9 (7.8–167.2) µm in MDAMB231^NOTCH4+ (n = 8) (median: minimum–maximum). There were A8 branches present in all tumors, but more branching orders (A9, A10) were present in MDAMB231^NOTCH4+ tissue. There were no significant differences in vessel diameter. The asterisk (*) indicates that a segment was not observed. The error bars show SD of the mean, except in (a) where MDAMB231^NOTCH4+ counts were based on two mice only and therefore error bars are omitted.

JOURNAL OF
SYNCHROTRON
RADIATION

ISSN: 1600-5775

Volume 24| Part 5| September 2017| Pages 1039-1047

https://doi.org/10.1107/S1600577517008372

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