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Figure 2
Relationship between radiation dose and CNR in CT scans of PTA stained mouse hearts embedded in paraffin. (a) Representative virtual slices of reconstructed raw data of a PTA stained paraffin embedded mouse heart, acquired at a low (5 kGy, left) and high (80 kGy, right) dose. (b) The same slices reconstructed after phase retrieval, resulting in reduced noise and a strong improvement of the image quality which depicts the anatomical structures of myocardial muscle fibers in more detail. In addition, dose-dependent crack formations in the paraffin are shown (white arrow heads). Note that the series of scans was started with high-dose scans, therefore the cracks appear larger at low dose. (c) By analyzing the CNR between heart muscle and paraffin [upper and lower red circle in (b), respectively] the phase-retrieved data (red curve) show around a tenfold increase in CNR at high dose and a less rapid decay at low dose than the reconstructed raw data. Note that at a dose of 5 kGy the CNR shows a 17-fold increase to the CNR of the reconstructed raw data (blue curve).

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