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Figure 7
A catalytic mechanism for phosphoglucose isomerase, shown here in the glucose 6-phosphate to fructose 6-phosphate direction. The reaction comprises three steps: (i) ring opening, which is shown here to be acid catalysed by His388, (ii) isomerization via a cis-enediol intermediate, in which Glu357 transfers a proton from C2 of G6P to C1 of F6P, and (iii) ring closure, in which His388 promotes ring closure by abstracting a proton from the hydroxyl group on C5.

Journal logoBIOLOGICAL
CRYSTALLOGRAPHY
ISSN: 1399-0047
Volume 59| Part 3| February 2003| Pages 453-465
doi:10.1107/S0907444902023387
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