Structural studies of glucose-6-phosphate and NADP+ binding to human glucose-6-phosphate dehydrogenase

Kotaka, M.; Gover, S.; Vandeputte-Rutten, L.; Au, S.W.N.; Lam, V.M.S.; Adams, M.J.

doi:10.1107/S0907444905002350

Acta Crystallographica Section D
Acta Crystallographica
Section D BIOLOGICAL CRYSTALLOGRAPHY

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Figure 7
Modelled structural NADP⁺ molecule in subunit B of ΔG6PD–G6P. The final 2|F_o| − |F_c| map, drawn in grey, is contoured at 1.25σ. The difference electron density, in blue, is contoured at 2.5σ. NADP⁺ was not included in F_c. Residues shown in black are in subunit B; those in red are in subunit A. Comparison with Fig. 6

(a) shows the exposure of charged residues in sheet strand βN when the residues of the tail are removed and the change in position of the side chain of both A421 and B421 in the absence of well bound NADP⁺.

BIOLOGICAL
CRYSTALLOGRAPHY

ISSN: 1399-0047

Volume 61| Part 5| April 2005| Pages 495-504

doi:10.1107/S0907444905002350

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