Application of the use of high-throughput technologies to the determination of protein structures of bacterial and viral pathogens

Fogg, M.J.; Alzari, P.; Bahar, M.; Bertini, I.; Betton, J.-M.; Burmeister, W.P.; Cambillau, C.; Canard, B.; Carrondo, M.; Coll, M.; Daenke, S.; Dym, O.; Egloff, M.-P.; Enguita, F.J.; Geerlof, A.; Haouz, A.; Jones, T.A.; Ma, Q.; Manicka, S.N.; Migliardi, M.; Nordlund, P.; Owens, R.J.; Peleg, Y.; Schneider, G.; Schnell, R.; Stuart, D.I.; Tarbouriech, N.; Unge, T.; Wilkinson, A.J.; Wilmanns, M.; Wilson, K.S.; Zimhony, O.; Grimes, J.M.

doi:10.1107/S0907444906030915

Acta Crystallographica Section D
Acta Crystallographica
Section D BIOLOGICAL CRYSTALLOGRAPHY

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Figure 2
Structures of representative bacterial targets described in §

4. All cartoons are drawn blue to red from the N- to the C-terminus. (a) Schematic view of the structure of sulfite reductase, NirA, from M. tuberculosis. The [Fe₄–S₄] cluster and siroheme cofactor are shown in ball-and-stick representation (Schnell et al., 2005

). (b) Schematic view of the structure of Neisseria IIAntr (NMB 0736) with the phosphoryl acceptor histidine residue (His67) indicated (Ren et al., 2005