From structure of the complex to understanding of the biology

Rossmann, M.G.; Arisaka, F.; Battisti, A.J.; Bowman, V.D.; Chipman, P.R.; Fokine, A.; Hafenstein, S.; Kanamaru, S.; Kostyuchenko, V.A.; Mesyanzhinov, V.V.; Shneider, M.M.; Morais, M.C.; Leiman, P.G.; Palermo, L.M.; Parrish, C.R.; Xiao, C.

doi:10.1107/S0907444906047330

Acta Crystallographica Section D
Acta Crystallographica
Section D BIOLOGICAL CRYSTALLOGRAPHY

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Figure 7
Diagrammatic representation of a T4 phage infecting E. coli. (a) The phage's long tail fibers (LTF) have found lipopolysaccharide (LPS) molecules on the surface of an E. coli cell. In addition, the short tail fibers (STF) have unfolded from the base of the baseplate to attach firmly to the E. coli surface. (b) The T4 tail sheath has contracted, pushing the tail tube with its gp5 `pin' through the outer membrane. (c) The gp5 pin falls off, leaving the lysozyme domain of gp5 ready to digest the peptidoglycan cell wall. (d) The tail tube can now penetrate further and allow the T4 DNA to enter the cytoplasm.

BIOLOGICAL
CRYSTALLOGRAPHY

ISSN: 1399-0047

Volume 63| Part 1| December 2007| Pages 9-16

doi:10.1107/S0907444906047330

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