POZ-domain sequence alignment. Sequence alignment of a selection of human POZ-TF POZ domains; sequences were aligned using ClustalW (Thompson et al., 1994). The observed secondary-structure elements of the Bach2 POZ-domain chains are indicated; α-helices are depicted as red cylinders and β-strands as blue arrows. The pink cylinder represents the sequence that corresponds to α6 in many POZ-TFs. All cysteine residues of the Bach2 POZ domain are highlighted in green and conserved cysteines of other POZ proteins are also indicated.