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Figure 1
Three-dimensional structure of CotA laccase: overall three-dimensional fold highlighting the entrance and exit channels, above and below the trinuclear cluster, for the dioxygen and water molecules, respectively. The three cupredoxin-like domains are coloured blue (domain 1), dark red (domain 2) and green (domain 3). Cu atoms are represented as spheres coloured yellow. Substrate oxidation occurs close to the mononuclear T1 Cu centre, shuttling electrons to the trinuclear Cu centre where dioxygen reduction occurs with the concomitant release of water molecules. |